氯诺昔康超前镇痛对应激的影响  

Effect of Pre-Emptive Analgesia with Lornoxicam on Stress Responses

作　　者：牟燕[1] 刘景诗[1] 

机构地区：[1]湖南省人民医院麻醉医学中心,湖南长沙410005

出　　处：《医学临床研究》2009年第10期1857-1859,共3页Journal of Clinical Research

摘　　要：【目的】观察氯诺昔康超前镇痛对应激的影响。【方法】选择40例因肝内外胆管结石拟行“T”管引流术或肝叶切除术患者，每组20例，随机分为L和H组，L组于麻醉前静脉滴注氯诺昔康8mg，H组术毕即刻静脉滴注氯诺昔康8mg，术后均以芬太尼行静脉给药病人自控镇痛（PCIA）。两组患者麻醉前、术毕0、6、24h四个时点各抽取外周静脉血8mL，测定血清C反应蛋白（CRP）、皮质醇（COR）、血糖（BS）。【结果】L组在选定时段CRP、COR、BS均显著低于H组（P〈0．05）。【结论】氯诺昔康术前较术后使用能更有效抑制应激反应。[Objective] To observe the effect of pre-emptive analgesia with lornoxicam on stress responses. [Methods]Forty cases who underwent elective T tube drain and lobectomy of liver for calculus of interhepatic and extrahepatic bile duct were selected and randomly divided into two groups with 20 cases each. Patients in group L were given lornoxicam 40mg iv. before the induction of anesthesia. In group H, patients were given lornoxicam 8mg at the end of operation. After the operation, fentanyl was administered via PCA in both two groups. The levels of C reactive protein （CRP）, cortisol （COR） and blood sugar （BS） in serum ahead of anes thesia induction and at Oh, 6h, 24h after operation were measured. [Results]Compared to group H,the levels of CRP, COR and BS in serum in group L in every select point was significantly decreased. [Conclusion] Preemptive analgesia with lornoxicam can effectively inhibit the stress responses during postoperation.

关 键 词：镇痛 应激 氧化还原酶类 

分 类 号：R971.1[医药卫生—药品] R614.2[医药卫生—药学]