非ST段抬高型急性冠脉综合征患者经皮冠脉介入治疗前后IL-10的变化  

Changes of IL-10 in Non-ST Elevation Acute Coronary Syndromes During Percutaneous Coro- nary Intervention

作　　者：刘智勇[1] 袁旭明[1] 何昕[1] 

机构地区：[1]南华大学附属浏阳医院,湖南浏阳410300

出　　处：《医学临床研究》2009年第10期1887-1889,共3页Journal of Clinical Research

摘　　要：【目的】探讨非ST段抬高型（NSTE）急性冠脉综合征（ACS）患者经皮冠脉介入治疗（PCI）前后血清IL-10浓度的变化及意义。【方法】稳定性心绞痛患者（SA）25例、非ST段抬高型ACS患者65例，其中不稳定心绞痛（UA）40例和非ST段抬高型心肌梗死（NSTEMI）25例，正常对照组25例，查血清IL-10的浓度。随后ACS组随机分为药物治疗组33例和PCI组32例，观察治疗前、术后d。及术后d1。血清IL-10的变化。【结果】按正常对照组、SA组、UA组及NSTEMI组排序，治疗前血清IL-10进行性升高[（1．79±0．42）VS（2．25±0．38）VS（4．14±0．84）VS（6．8±1.06）pg／mL]；NSTEACS患者的血清IL-10经药物治疗后逐渐降低[（5．34±0．76）vs（5．04±0．81）VS（3．86±0．51）pg／mL，P〈0．05]，而PCI组在术后d1迅速升高，随后明显下降[（5．21±0．82）vs（9．42±1．28）VS（2．31±0．47）pg／mL，P〈0．01]，d10时PCI组的血清IL-10明显低于药物治疗组[（2．31±0．47）VS（3．86±0．51）pg／mL，P〈0．01]。【结论】血清IL-10作为抗炎细胞因子，其升高和降低能一定程度上反映NSTEACS患者心肌缺血的程度；PCI能显著改善NSTEACS患者的心肌供血，并且在减轻近期冠脉血管局部炎症上较常规的药物治疗可能更加有效。[Objective]To assess the change of serum interleukin 10 （IL-10） in patients with Non ST ele vation （NSTE） acute coronary syndromes （ACS） before and after pereutaneous coronary intervention （PCI） and its significance. [Methods]Twenty five patients with stability angina pectoris （SA）, 65 patients with NSTE ACS including 40 patients with unstable angina pectoris （UA） and 25 patients with Non-ST elevation myocardial infarction（NSTEMI）,and 25 control subjects were investigated. Serum IL-10 was measured. The patients with ACS were randomly divided into PCI group and conservative therapy group. And serum IL -10 was measured before and 1, 10 day after PCI. [Results]Serum IL - 10 levels in control subjects, SA, UA and NSTEMI patients were （1.79±0.42） , （2.25±0.38） , （4.14±0.84） and （6.8±1.06） pg/mL, respectively, and there were significant differences among four groups. Serum IL-10 in NSTE ACS group was gradually de creased after conservative therapy. But it significantly increased at 1 day after PCI, and then significantly decreased at 10 day. And there was significant difference in serum IL- 10 between PCI group and conservative therapy group at 10 day[（2.31±0.47）vs（3.86±0.51）pg/ml, P〈0.01]. [Conclusion]IL-10 as the anti inflammatory cytokine reflects the degree of myocardial ischemia in patients with NSTE ACS at some extent. PC1 perhaps is more effective than conservative therapy in relieving myocardial ischemia and reducing the recently local inflammation of coronary artery in patients with NSTE ACS.

关 键 词：冠状动脉疾病/治疗 急性病 血管成形术 经腔 经皮冠状动脉 白细胞介素10 

分 类 号：R543.3[医药卫生—心血管疾病]