2-吡啶甲醇的合成研究  

Synthesis of 2-pyridine Methanol

作　　者：桂伦[1] 郑典模[1] 叶焕英[1] 刘辉[1] 

机构地区：[1]南昌大学环境与化学工程学院,江西南昌330031

出　　处：《江西科学》2009年第5期767-770,共4页Jiangxi Science

摘　　要：2-吡啶甲醇不仅是一种新开发的治疗心血管疾病药物的中间体,也是很多重要药物的中间体。介绍以2-甲基吡啶为原料,经氧化,酰化重排,水解制备2-吡啶甲醇的工艺路线。简述了反应的机理、合成方法及研究进展,并对影响反应的各种因素进行了比较。2-pyridinemethanol is not only an drug intermediates of the newly developed of treatment of cardiovascular diseases intermediates,but also many important drug intermediates. This paper describes the process route,which takes 2-methylpyridine as the raw material for the preparation of 2- pyridinemethanol through oxidation, rearrangement acylation, hydrolysis, etc. This paper mainly summarizes the reaction mechanism, synthesis methods and research progress. And a variety of factors affect the reaction are compared.

关 键 词：2-吡啶甲醇 乙酸2-吡啶基甲酯 吡啶氧化物 

分 类 号：TQ253.2[化学工程—有机化工]