氧化低密度脂蛋白损伤血管内皮功能的机制及相关药物研究现状  

Current Status of Research on the Mechanism of Oxidized Low Density Lipoprotein-induced Endothelial Dysfunction and the Related Drugs

作　　者：宋军娜[1] 刘康[1] 刘保林[1] 

机构地区：[1]中国药科大学中药药理学教研室,江苏南京210009

出　　处：《药学进展》2009年第10期433-438,共6页Progress in Pharmaceutical Sciences

摘　　要：综述近年来有关氧化低密度脂蛋白损伤血管内皮功能的机制及相关药物研究进展。低密度脂蛋白经氧化修饰后主要通过凝集素样氧化低密度脂蛋白受体-1介导血管内皮损伤;破坏血管舒缩因子之间的作用平衡,致使血管舒缩功能障碍;诱导黏附分子和致炎因子的合成和释放,加重血管炎症反应;诱导内皮细胞凋亡,进而导致动脉粥样硬化等血管疾病。The （ox-LDL） -induced mediate endothelial recent progress in reseach on the mechanisms of oxidized low density lipoprotein endothelial dysfunction and the related drugs was reviewed. Ox-LDL is believed to damage via LOX-1, to disturb the balance of vessel diastolic and systolic factors inducing vasomotion dysfunction, to induce synthesis and release of adhesion molecules and proinflammatory cytokines aggravating vessel inflammatory reaction, and to induce endothelial cell apoptosis leading to vascular anomalies including atherosclerosis.

关 键 词：氧化低密度脂蛋白 内皮功能损伤 凝集素样氧化低密度脂蛋白受体-1 黏附分子 致炎因子 凋亡 

分 类 号：R543[医药卫生—心血管疾病] R972[医药卫生—内科学]