惊恐障碍患者人格特征、交感皮肤反应及血清白介素-2水平的研究  

The study of personality characteristics, sympathetic skin response and immune parameter interleukin-2 in the patients with panic disorder

作　　者：刘效巍[1] 许晶[1] 李青栋[1] 姜国晶[1] 

机构地区：[1]大连医科大学附属第一医院神经内科,大连116011

出　　处：《中华行为医学与脑科学杂志》2009年第10期871-873,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金资助项目（30570477）;大连市科委基金资助项目（2005E21SF133）

摘　　要：目的探讨惊恐障碍（PD）患者的人格特征、交感皮肤反应及血清白介素-2（IL-2）水平。方法对32例PD患者（PD组）和32名正常对照组（NC组），采用艾森克人格问卷（EPQ）评定其人格特征，采用汉密尔顿焦虑量表（HAMA）和90项症状清单（SCL-90）评定其焦虑程度及心理健康水平，应用肌电图／诱发电位仪记录其交感皮肤反应（SSR）。采用放射免疫法测定血清IL-2水平。结果（1）PD组EPQ评分的神经质和掩饰性显著高于对照组（P〈0．05）。PD组HAMA评分、SCL-90评分显著高于对照组（P〈0．05）。PD组的N分与SCL-90中的躯体化、抑郁、焦虑因子及HAMA评分存在Spearman正相关（P〈0．05）。（2）PD组SSR波幅较NC组显著增高[左侧：（3．03±2．43）mV，（1．22±0．7）mV（P〈0．01）；右侧：（2．33±1．41）mV，（1．26±0．71）mV（P〈0．01）]。（3）PD组血清IL-2水平显著低于NC组[（2．18±0．87）ng/ml，（5．0±1．5）ng／ml（P〈0．01）]。结论PD患者存在高神经质、情绪不稳定的人格特征，并且影响其心理健康水平；PD患者交感神经活性增强；PD患者免疫功能失衡。Objective To investigate personality characteristics, sympathetic skin response（SSR） and interleukin-2（IL-2 ） levels in patients with panic dosorder. Methods 32 PD patients and 32 normal controls matched by sex and age were enrolled in the study. The two groups were assessed with Eysenck Personality Questionnaire （ EPQ）, Symptom Checklist 90 （SCL-90） and Hamilton Anxiety Scale （HAMA）. The correlations between them were investigated. SSR was recorded by the EMG instrument and IL-2 level in serum was measured with radioimmunoassay. Results （ 1 ） AS compared with controls ,the patients had significantly higher EPQ-N score and EPQ-L score. The SCL-90 score and HAMA score in the patients were significantly higher than those in controls. Furthermore,N score in the patients displayed a positive spearulan-correlation with somatization score,depression score, anxiety score and HAMA score. （2）Compared with controls, the patients showed increased SSR amplitudes [left：（3.03 ±2.43）mV vs （1.22 ±0.7） mV（P〈0.01） ;right： （2.33 ±1.41）mV vs （1.26 ±0.71） mV（P〈 0. 01 ） ] ; （3） The concentration of IL-2 in the patients was significantly lower than that of the controls [ （ 2.18 ± 0.87 ）ng/ml vs （5.0 ±1.5 ）ng/ml（P 〈 0.01 ）]. Conclusion These data indicate that PD patients display high neurotieism and emotional instability, which probably effects patients＇ mental health level. PD patients exist excitability of sympathetic system and disbalance of immunity.

关 键 词：惊恐障碍 人格特征 交感皮肤反应 白介素-2 

分 类 号：R686[医药卫生—骨科学]