不同间歇期情感障碍患者的临床对照研究  

Characteristics of the reoccurrence inpatients with mood disorder with a different intermission period

作　　者：王爱荣[1] 苏中华[1] 李玉梅[1] 张秀贞[1] 张仲荣[1] 

机构地区：[1]山东省济宁市精神病防治院,济宁272051

出　　处：《中华行为医学与脑科学杂志》2009年第10期894-896,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：济宁市科技局资助项目（2007-26）

摘　　要：目的探讨不同间歇期情感性精神障碍患者的临床特点，以利指导治疗和估计预后。方法研究对象为第2次发作住院治疗的情感性障碍患者，根据2次发作间歇期的长短，分为长间歇期组（间歇期≥5年，下称研究组）和短间歇期组（间歇期〈5年，下称对照组）。应用自编调查表收集相关资料，抑郁发作患者评定汉米尔顿抑郁量表和临床疗效总评量表的严重程度分量表（SI），躁狂发作患者评定躁狂量表和SI。结果研究组目前年龄平均（45．32±14．13）岁，大于对照组的（39．71±13．26）岁，差异有显著性（t=2．50，P〈0．01）；研究组女性占63．83％，对照组44．78％，差异有显著性（χ^2=8．24，P〈0．01）；研究组外向性格63．33％，对照组40．43％，差异有显著性（χ^2=6．69，P〈0．01）；研究组家族史阳性率45．00％，对照组69．15％。差异有显著性（χ^2=4．37，P〈0．01）；研究组伴有精神病性症状的38．33％，对照组86．17％，差异有显著性（χ^2=9．54，P〈0．01）。结论长间歇期情感性精神障碍患者女性偏多，性格外向者多，家族史阴性者多，而伴精神病性症状少，疾病严重程度轻.Objective To understand the characteristics of the reoccurrence inpatients with mood disorder with a different intermission, and to support the guides of treatment and estimate prognosis for them. Methods Based on the intermission period between two episodes, the inpatients met the diagnostic mrteria of mood disorder in CCMD-3 were divided into longer intermission duration group （ ≥5 years, n = 60） and lower intermission duration group （ 〈 5 years, n = 94）. The information of the patients on demography and ill-related characteristics were collected by self-developed questionnaire. The psyeholepsy patients were evaluated by HAMD and SI. The manic episode patients were evaluated by BRMS and SI. Results The ratio of female and extroversion personality in the longer intermission group were significant higher than those in the lower intermission group （ 68.33 % vs 44.78 % , t = 8.24, P = 0. 005 ;63.33 % vs 40.43 % , t = 6.89, P = 0. 006）. The proportion of positive family history was higher in the longer intermission group than in the lower intermission group （ 45.00% vs 69.15% , t = 4.37, P = 0.00）. The proportion of psychosis symptoms was higher in the longer intermission group than in the lower intermission group （38.33% vs 86.17% , t = 9.54, P= 0.00）. The inpatients with lower intermission were more severe, companied by psychotic symptoms. Conclusion The inpatients with mood disorder, who have a longer intermission periods,have less psychotic sympotoms, female was predominant and more extrover- sion.

关 键 词：情感性障碍 间歇期 抑郁发作 躁狂发作 临床特点 

分 类 号：R686[医药卫生—骨科学]