氟伏沙明合并认知行为疗法治疗强迫症的临床疗效  

Clinical effect of the treatment of fluvoxoxamine combined with cognitive behavioral therapy on obsessivecompulsive disorders

作　　者：王微[1] 张惠梅[1] 贾传鲁 张茹[1] 

机构地区：[1]济宁医学院附属医院,济宁272029 [2]兖矿集团东滩矿医院

出　　处：《中华行为医学与脑科学杂志》2009年第10期897-898,共2页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的探讨氟伏沙明合并认知行为疗法（CBT）治疗强迫症（OCD）的临床疗效。方法符合入组标准的强迫症患者，按随机数字表法分为氟伏沙明合并认知行为治疗组（研究组）、单纯认知治疗组（对照组），观察比较治疗1，3，6个月后Yale-Brown强迫量表评分情况及临床疗效。结果研究组治疗6个月后有效率71％，对照组有效率42．7％，差异有显著性（P〈0．01）。2组Yale—Brown强迫量表总得分在治疗3个月后和6个月后差异有显著性，研究组显著低于对照组[（18．86±6．47）分，（17．10±7．20）分；（15．16±6．88）分，（12．70±7．31）分；P〈0．05]。结论认知行为治疗合并药物治疗强迫症的疗效明显优于单纯认知行为治疗。Objective To explore the effect of the treatment of fluvoxoxamine combined with cognitive behavioral therapy （CBT） on obsessive-compulsive disorders （ OCD ）. Methods After defining the diagnosis, 110 OCD patients were divided into study group（ n = 62） and control group （ n = 48 ） according to their own will, and Yale-Brown obsessive-compulsive scale,the assessment of the clinical effect was used to assess in 1,3,6 months later. Results The group of cognitive behavioral therapy combining pharmacological therapy was 62 cases, and the clinical effective rate was 71.0%. The group of cognitive behavioral therapy was 48 cases, and the clinical effective rate was 42.7% . In the 3 and 6 months ,there was significant difference in the marks between Yale-Brown obsessive-compulsive scale of the two groups （P 〈 0.05 ）. Conclusion The effectiveness of the CBT combining pharmacological therapy is better than simple CBT therapy.

关 键 词：认知行为治疗 强迫症 病例对照研究 相关性 

分 类 号：R686[医药卫生—骨科学]