双氯芬酸盐酸利多卡因和杜冷丁治疗肾输尿管绞痛的疗效对比  

Dolantin versus Compound Diclofenac Sodium and Lidocaine Hydrochloride(CDL) in the treatment of acute ureteral colic

作　　者：邹顺[1] 李雪松[1] 李小军[1] 

机构地区：[1]昆明医学院第一附属医院药剂科,650031

出　　处：《中国现代药物应用》2009年第21期5-7,共3页Chinese Journal of Modern Drug Application

摘　　要：目的评价双氯芬酸利多卡因(CDL)对肾输尿管绞痛的可行性和安全性。方法152例肾输尿管绞痛患者随机分为CDL组(n=76)和杜冷丁组(n=76)。CDL组肌肉注射双氯芬酸75mg和利多卡因20mg镇痛;杜冷丁组肌肉注射杜冷丁50mg。采用四点口述分级法和数字疼痛分级法分析镇痛效果,同时观察药物不良反应。结果CDL组镇痛起效时(14.7±6.8)min与杜冷丁组(15.6±5.3)min无统计学差异(P>0.05);给药后4h内间两组镇痛效果NRS评分无统计学差异(P>0.05),但4h后CDL组的得分逐渐低于杜冷丁组,至6～8h出现统计学差异(P<0.05)。疼痛缓解持续时间CDL组(5.12±1.3h)长于杜冷丁组(3.8±1.7h),差异具有统计学意义(P<0.05)。不良反应发生总频次CDL组(27)少于杜冷丁组(80),差异具有统计学意义(P<0.01)。结论CDL治疗肾输尿管绞痛镇痛安全有效且不良反应发生频次少于杜冷丁。Objective To assess the efficacy and feasibility of intramuscular CDL in the relief of acute renal colic. Methods 152 patients admitted to the emergency room for renal colic were divided randomly into CDL arm（ n = 76 ） or Dolantin arm（ n = 76 ）. CDL ann patients were assigned to treatment with either intramuscular injection for 75 mg CDL or dolantin 50 mg. Pain was self-assessed using a 4-point verbal rating scale （VRS-4） and a Numeric rating scale （NRS） just before drug administration and 15, 30, 60 120,240,360 and 480 minutes later. Results The 2 arms were similar with regard to baseline characteristics （ P 〉 0. 05 ）. The scores of patients who reported an improvement in the VRS in 240 min post-administration （ primary variable） between CDL ann and Dolantin arm were not siginificant（ P 〉 0.05 ）, but significant low in CDL ann compared with Dolantin arm from 6 h - 8 h（ （P 〈 0. 05 ））. The time of renal colic lasted relief in CDL arm（ 5. 12 ± 1.3 h） showed significant longer （ P 〈 0. 05 ） than Dolantin arms 3.8 ± 1.7 h）. Mild to moderate adverse events were reported by 27 frequency of patients receiving CDL and by 80 frequency of patients receiving dolantin （ P 〈 0. 01 ）. Conclusion CDL should be recommend to clinician because it is uhility and silty in the relief of acute ureteral colic, and the adverse events of CDL are less than dolantin.

关 键 词：双氯芬酸利多卡因(CDL) 杜冷丁 肾输尿管绞痛 

分 类 号：R691[医药卫生—泌尿科学]