EPO/EPOR及其信号转导机制研究进展  

Progress in the study on EPO/EPOR and its signal transduction

作　　者：葛全兴[1] 陈垦[1] 龙友明[1] 王晖[2] 

机构地区：[1]广东药学院临床医学院内科学教研室,广州510310 [2]广东药学院中药学院药理学教研室,广州510006

出　　处：《国际病理科学与临床杂志》2009年第5期416-420,共5页Journal of International Pathology and Clinical Medicine

摘　　要：红细胞生成素(erythropoietin,EPO)和红细胞生成素受体(erythropoietin receptor,EPOR)是调节红系祖细胞增殖、分化和生存所必需的关键细胞因子。近年来,国内外研究进一步发现,EPOR不仅存在于幼红细胞,在其它细胞也有发现,EPO和EPOR的作用更为广泛。本文对EPO/EPOR及其细胞内外一系列信号转导机制进行综述。Erythropoietin （EPO） and erythropoietin receptor （EPOR） are the essential key cytokines in regulating the proliferation, differentiation and survival of erythroid progenitors. Recently, more and more studies have demonstrated that EPOR also exists in other type of cells in addition to normoblasts, suggesting that EPO and EPOR may have much more extensive biological functions. Here, we reviewed the intracellular signal transduction pathways activated by the EPO and the underlying mechanisms.

关 键 词：红细胞生成素 红细胞生成素受体 信号转导 机制 

分 类 号：Q26[生物学—细胞生物学]