MicroRNAs在心血管疾病中作用的研究进展  

Role of microRNAs in cardiovascular disease

作　　者：徐竞鸥[1] 欧和生[1] 

机构地区：[1]南华大学药物药理研究所,湖南衡阳421001

出　　处：《国际病理科学与临床杂志》2009年第5期451-455,共5页Journal of International Pathology and Clinical Medicine

摘　　要：MicroRNAs（miRNAs）是一类长度为21～28nt单链非编码小分子RNA，通过与靶基因3＇-UTR完全或不完全互补配对结合导致靶基因降解或翻译抑制调节几千种基因。近年研究表明miRNAs已成为许多重要生物过程的主要调节因子，包括生长发育、细胞增殖、分化和凋亡等。研究对应miRNAs参与疾病发生的机制可能为人类某些疾病的治疗开辟一条新的途经。本综述总结miRNAs在调控心血管疾病发生的作用方面的研究成果。MicroRNAs （miRNAs） is a kind of 21 -28 nt single-stranded, non-coding small molecular RNA, which can regulate thousands of genes through binding to 3＇-UTR of target genes in a pattern of full or partial complementary pairing, and results in degradation or translation inhibition of target genes. Recently, it has been shown that miRNAs has become a key regulator of many bioprocess including growth and development, cell proliferation, differentiation and apoptosis. To elucidate the role of microRNAs in diseases may provide a novel strategy for the therapy of many diseases. This review summarized the progress in the study on role of miRNAs in cardiovascular diseases.

关 键 词：MIRNAS 心血管疾病 作用 

分 类 号：R54[医药卫生—心血管疾病]