二月桂酸二丁基锡对大鼠肝脏NO含量及GSH-PX活性的影响  

Effect of DBTD on the Contents of NO and Activity of GSH-PX of Liver in Rats

作　　者：宋祥福[1] 栗娜[2] 朱健[1] 栗学军[1] 

机构地区：[1]吉林大学公共卫生学院,长春130021 [2]吉林省人民医院,长春130021

出　　处：《中国比较医学杂志》2009年第9期41-43,共3页Chinese Journal of Comparative Medicine

摘　　要：目的探讨二月桂酸二丁基锡(DBTD)对大鼠肝脏NO含量及GSH-PX活性的影响。方法NO试剂盒测定NO含量;GSH-PX试剂盒测定GSH-PX活性。结果NO含量各染毒组与对照组比较均有显著性差异(P<0.05);GSH-PX的活性随染毒剂量的升高而降低,与对照组比较均有显著性差异(P<0.05)。结论DBTD可使肝组织NO含量增高;GSH-PX活性下降。Objective To investigate the effects of DBTD on the contents of NO and activity of GSH-PX of liver in Rats. Method The contents of NO and the activity of GSH-PX was individually tested with their own kit. Results There were significantly different on the accounts of NO between the exposured group and control group （P 〈 0.05）. The activity of GSH-PX decreased as the dose of DBTD increased. It obviously decreased to the control group （P 〈 0.05 ）. Conclusion DBTD can increase the contents of NO and decrease the activity of GSH-PX of liver.

关 键 词：二月桂酸二丁基锡(DBTD) 一氧化氮(NO) 谷光甘肽过氧化物酶(GSH-PX) 

分 类 号：R454.2[医药卫生—治疗学] R994.6[医药卫生—临床医学]