FGF10及其受体FGFR1、FGFR2在昆明小鼠输卵管和子宫内的分布  

Distribution of FGF10,FGFR1 and FGFR2 in the Mouse Oviduct and Uterus

作　　者：谢美容[1] 王章敬[2] 林翠英[1] 吕俊杰[1] 张卫玉[1] 王建新[1] 王世鄂[1] 

机构地区：[1]福建医科大学基础医学院人体解剖学与组织胚胎学系神经生物学研究中心,福建福州350004 [2]福建医科大学公共卫生学院预防医学实验中心,福建福州350004

出　　处：《解剖科学进展》2009年第3期257-260,共4页Progress of Anatomical Sciences

基　　金：福建省高等学校新世纪优秀人才支持计划项目(No.NCETFJ-0601)

摘　　要：目的观察成纤维细胞生长因子10(FGF10)、成纤维细胞生长因子受体(FGFR1、FGFR2)在昆明小鼠输卵管和子宫内的定位与分布。方法应用免疫组织化学法进行蛋白质定位观察。结果FGF10和FGFR1免疫阳性反应定位于昆明小鼠输卵管上皮细胞,FGFR2的免疫阳性反应见于肌层平滑肌。FGF10和FGFR1免疫阳性反应分布于昆明小鼠子宫内膜上皮、子宫腺上皮和肌层平滑肌,而FGFR2免疫阳性反应见于肌层平滑肌。结论FGF10及其受体在输卵管和子宫的分布可能参与输卵管和子宫的重要功能。Objective To investigate the distribution of fibroblast growth factor 10（FGF10）, fibroblast growth factor receptor 1,2 （FGFR1, FGFR2） in the mouse oviduct and uterus. Methods Immunohistochemistry was used to observe the distribution of FGF10, FGFR1 and FGFR2 in the Kunming（KM） mouse oviduct and uterus. Results FGF10 positive and FGFR1 positive immunoreaetivities were found in the oviductal epithelium, FGFR2 positive immunoreactivity was located in the muscular layer of KM mouse. FGF10 positive and FGFR1 positive immunoreactivities were observed in the uterine endometrial epithelium, the glandular epithelium and the myometrium, but FGFR2 positive immunoreactivity was found in the myometrium of KM mouse. Conclusion The expression of FGF10, FGFR1 and FGFR2 in the oviduct and uterus indicates that they might play a role in the oviduct and uterus.

关 键 词：成纤维细胞生长因子10 成纤维细胞生长因子受体1 成纤维细胞生长因子受体2 输卵管 子宫 小鼠 

分 类 号：R329.465[医药卫生—人体解剖和组织胚胎学]