所见即所学,所学有所用--2009年诺贝尔化学奖简介  

What You See Is What You Learn,What You Learn Guides What You Do——Introduction to the Contribution of the Awardees of Nobel Prize in Chemistry 2009

作　　者：路钊[1] 丁卫[1] 

机构地区：[1]首都医科大学基础医学院生物化学与分子生物学系

出　　处：《首都医科大学学报》2009年第5期723-726,共4页Journal of Capital Medical University

摘　　要："所见即所学"已成为结构生物学研究的信条,2009年荣获诺贝尔化学奖的3位美国和以色列科学家通过利用高分辨度晶体解析对核蛋白体在蛋白质合成功能中的结构基础进行阐述,再次对此作出了生动的展示。他们的工作不仅揭示了重要生命现象的化学本质,同时也拓展了在相关药物(如抗生素等)开发中的应用,对生命科学和医学的基础研究具有深远的影响。＂What you see is what you learn＂ is believed to be the essence of the structural biology research. In the 2009 Nobel Prize in Chemistry awarded work, three outstanding scientists from the United States and Israel have vividly demonstrated that how highresolution crystallography not only helped to solve long-standing problems in the structural-functional studies for the roles of ribosomes in the process of protein biosynthesis, but also revealed the underlying mechanisms. Their contributions have provided far-reaching implications for basic biological and medical sciences, and meanwhile inspired and expanded the important applications for related drug development, such as the designs of antibiotics.

关 键 词：高分辨度晶体解析 核蛋白体 诺贝尔化学奖 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学] R979.1[医药卫生—基础医学]