透明颤菌血红蛋白的研究与发展前景  

Vitreoscilla Hemoglobin Research and Development Prospects

作　　者：凌永胜[1,2] 杜娟[1] 肖宇[1] 胡晓倩[1] 林忠平[1] 

机构地区：[1]北京大学生命科学学院,北京100871 [2]福建省泉州市农业科学研究所,晋江362212

出　　处：《生物技术通报》2009年第11期1-7,共7页Biotechnology Bulletin

基　　金：转基因生物新品种培育科技重大专项(2009ZX08004-003B)

摘　　要：在缺氧条件下,透明颤菌血红蛋白(VHb)通过促进氧输送增强呼吸和能量代谢,并在各种宿主中表达,显示出改善增长,蛋白质分泌,代谢产物的生产力和提高宿主抗逆性等的生理效应,从而使蛋白质在代谢工程尤其在优化植物代谢中应用前景广阔。概括了VHb在生物技术工业的诸多研究领域中的应用潜力,探讨VHb功能的细胞机制,并显示出各领域所采取的各种方法。In hypoxic conditions, bacteria express a kind of hemoglobin, which is proposed to enhance respiration and energy metabolism by promoting oxygen delivery. Bacteria hemoglobin from Vitreoscilla stercoraria-Vitreoscilla hemoglobin （VHb）, when expressed in various hosts in oxygen-limited conditions, has been shown to improve growth, protein secretion, metabolite productivity and stress resistance of hosts, thus rendering the protein promising in metabolic engineering, especially in plant metabolism optimization. In this review, many well-studies areas are presented to illustrate the potential of VHb application in biotechnology industry, to discuss the cellular mechanisms of VHb function and show the wide variety of approaches taken within the field.

关 键 词：透明颤菌血红蛋白 代谢工程 植物生物技术 

分 类 号：Q93[生物学—微生物学]