HIE新生儿血清NSE、Cor、ADM、钙、镁及血小板测定的临床意义  

Clinical Significance of Changes of Serum NSE,Cortisol,ADM,Calcium,Magnesium Levels and Platalet Count in Neonates with Hypoxic-Ischemic Encephalopathy(HIE)

作　　者：吕卫华[1] 黄卫良[1] 

机构地区：[1]扬州大学第五临床医学院常熟二院儿科,215500

出　　处：《放射免疫学杂志》2009年第5期444-446,共3页Journal of Radioimmanology

摘　　要：目的:探讨HIE患儿血清NSE、Cor及ADM测定的临床意义。方法:NSE、ADM均采用放射免疫分析,Cor测定则应用化学发光法;用邻甲酚酞络合酮法测定血清总钙,络合指示剂法测定血清镁;血小板计数应用Sysmex2100全自动血细胞分析仪测定。结果:轻度HIE组NSE及ADM两项指标与对照组比较差异无显著性(P>0.05);Cor水平则轻度组较对照组显著升高(P<0.05)。中度HIE组NSE和Cor两项指标与对照组比较升高均极显著(P均<0.01);ADM水平较对照组升高亦具显著性(P<0.05)。重度组两项指标较对照组升高均极显著(P均<0.01)。血清总钙、镁及血小板两项指标的测定数据则均降低非常显著,与对照组相比(P均<0.01),差异有明显统计学意义,轻、中、重三组间三项血常规参数降低也较明显;三组间两两比较(P均<0.05),差异有统计学意义。结论:六项指标均参与了患儿HIE的发病过程,其测定对于了解患儿脑损伤程度有帮助。Objective To study the clinical significance of changes of serum NSE,cortisol,ADM,Ca＋＋,Mg＋＋ levels and platalet count in neonates with HIE.Methods Serum NSE,ADM（with RIA）,cortisol（with CLIA）,Ca＋＋ and Mg＋＋（with biochemistry） levels and platalet count were determined in 52 neonates with HIE（mild,n=26,moderate,n=16,advanced,n=10） and 30 controls.Results In the neonates with mild HIE,the serum NSE and ADM levels were not significantly different from those in controls（P〉0.05） but cortisol levels were significantly higher（P〈0.05）.In neonates with HIE of moderate degree,the serum NSE,cortisol（P〈0.01） and ADM（P〈0.05） levels were all significantly higher than those in controls.In neonates with advanced HIE,serum NSE,cortisol and ADM were all very significantly higher than those in controls（P〈0.01）.The serum calcium,magnesium levels and platalet count in all the HIE neonates were significantly lower than those in controls,with significant differences among the 3 groups of HIE patients.Conclusion Magnitude of the changes of serum NSE,cortisol,ADM,Ca＋＋ and Mg＋＋ levels as well as decrease of platelet count,might reflect the severity of the disease process of HIE in neonates and might be of prognostic importance.

关 键 词：缺氧缺血性脑病 神经元特异性烯醇化酶 皮质醇 肾上腺髓质素 

分 类 号：R446.111[医药卫生—诊断学] R722.12[医药卫生—临床医学]