DM2患者血清TI、C-肽、GAD-Ab、INS-Ab检测在临床的应用  

Study on the Relationship Between Changes of Serum True Insulin(TI) C-peptide,GAD-Ab,INS-Ab Contents and Age,Course of Disease,Degree of Obesity in Patients with DM2

作　　者：杜同信[1] 王自正[1] 曹继伟[1] 吴锦丹[2] 陶晓军[2] 

机构地区：[1]南京医科大学附属南京第一医院核医学科,210006 [2]南京医科大学附属南京第一医院南京市糖尿病中心,210006

出　　处：《放射免疫学杂志》2009年第5期526-529,共4页Journal of Radioimmanology

摘　　要：目的:通过对2型糖尿病(DM2)患者血清C-肽、真胰岛素(TI)、胰岛素抗体(INS-Ab)、谷氨酸脱羧酶抗体(GAD-Ab)检测,探讨DM2年龄、体重、病程与其相互关系。方法:分别用化学发光、放射免疫分析、酶联免疫分析对428例DM2患者血清C-肽、TI、INS-Ab、GAD-Ab检测,分析和观察DM2患者在不同年龄、体重、病程组别中的四项指标的变化。结果:DM2患者不同年龄组与正常对照组比较有显著性差异(P<0.01),DM2患者不同年龄组之间比较也有显著性差异(P<0.05);非肥胖组与肥胖症组和超肥胖组四项结果比较均有显著性差异(P<0.05),肥胖组与超肥胖组比较(P<0.05);DM2患者各病程组之间的比较四项检测结果均有显著性差异(P<0.05)。结论:DM2患者随着年龄、体重、病程的变化,其血清C-肽、TI、INS-Ab、GAD-Ab等标志物水平也跟随变化,说明该标志物参与了DM2的发生和发展。Objective To study the changes of serum TI,C-peptide,GAD-Ab and INS-Ab in different groups of patients with DM2（age,course of disease and degree of obesity）.Methods Serum C-peptide（with CLIA）,INS-Ab（with RIA） and TI,GAD-Ab（with ELISA） contents were measured in altogether 428 patients with DM2.Relationship between changes of the above parameters and different groups of patients was studide in accordance with age,course of disease and degree of obesity respectively.Results ① Relationship among different age groups：（below 50,n=86,5170,n=216,over 71 n=126） The serum levels of the 4 parameters were significantly higher in all age group than those in the controls（n=40）.Among the various age groups,the levels of all parameters were significantly lower in age group below 50 than the levels,in the other 2 groups with the only exception of INS-Ab,which was not significantly different from that in age group 5170.The levels were significantly different between age-group 5170 and age groups over 70,with the only exception of GAD-Ab,which was about the same in the two age-groups.② Relationship between changes of serum levels and course of disease（below 5yrs n=157,610yrs n=168,over 1yrs,n=103）.The serum levels in patients with disease less than 5years were significantly lower than those in other groups with the exception of GAD-Ab,which was not significantly different from that in patients with disease 610 years.③ Relationship among different degree of obesity（non-obese,BMI〈25 n=176,obese 32〉BMI≥25,n=202,super-obese BMI≥32 n=50）： The serum levels of all the parameters were significantly lower in the non-obese subjects than those in the other two groups.The levels in the super-obese group were also significantly higher than those in the obese group（P〈0.01,P〈0.05）.Conclusion Serum levels of the 4 parameters（TI,C-peptide,GAD-Ab,INS-Ab） were significantly increased in patients with DM2,especially in the older patients with prolonged course of disease as well as in the ve

关 键 词：2型糖尿病 真胰岛素 谷氨酸脱羧酶抗体 胰岛素抗体 

分 类 号：R587.1[医药卫生—内分泌] R657.5[医药卫生—内科学]