冠心病患者血清hs-CRP、IL-18和IL-1β检测的临床意义  

Clinical Significance of Determination of Serum hs-CRP,IL-18 and IL-1β Levels in Patients with Coronary Heart Diseases

作　　者：王露[1] 全媛[1] 

机构地区：[1]江苏省姜堰市人民医院检验科,225500

出　　处：《放射免疫学杂志》2009年第5期543-544,共2页Journal of Radioimmanology

摘　　要：目的:探讨冠心病患者血清hs-CRP、IL-18和IL-1β水平的变化及意义。方法:应用免疫比浊法和ELISA对62例冠心病患者进行了血清hs-CRP、IL-18和IL-1β检测,其中稳定型心绞痛26例,不稳定型心绞痛22例,急性心肌梗死14例,并以35名正常健康人作比较。结果:冠心病患者血清hs-CRP、IL-18和IL-1β水平明显地高于正常人组(P<0.01),急性心肌梗死组和不稳定型心绞痛组又明显地高于稳定型心绞痛组(P<0.01)。结论:血清hs-CRP、IL-18和IL-1β水平的变化与冠心病的发生和发展有关。Objective To explore the significance of determination of serum contents of hs-CRP,IL-18 and IL-1β in patients with coronary heart diseases（CHD）.Methods Serum hs-CRP（with immuno-turbidity） and IL-18,IL-1β（with ELISA） contents were determined in 62 patients with CHD.（26SAP,22UAP,14AMI） and 35 controls.Results Serum levels of hs-CRP,IL-18 and IL-1β in CHD patients were significantly higher than those in controls（P〈0.01）.Among the CHD patients,the levels of hs-CRP and IL-18,IL-1β in AMI and UAP groups were significantly higher than those in SAP groups（p〈0.01）.Conclusion The serum levels of hs-CRP,IL-18 and IL-1β were correlated to the development of CHD.

关 键 词：冠心病 超敏C-反应蛋白 白细胞介素-18 白细胞介素-1Β 稳定性心绞痛 不稳定型心绞痛 急性心肌梗死 

分 类 号：R392[医药卫生—免疫学] R541.4[医药卫生—基础医学]