盐酸西替利嗪凝胶剂的制备及体外透皮特性  

Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel

作　　者：高翔[1] 张晨曦[2] 杨明[1] 刘继勇[3] 

机构地区：[1]第二军医大学药学院,05级本科生上海200433 [2]中国人民解放军第305医院药材科,北京100017 [3]第二军医大学长海医院药学部,上海200433

出　　处：《药学实践杂志》2009年第5期367-369,共3页Journal of Pharmaceutical Practice

基　　金：国家自然科学基金(30801557)

摘　　要：目的:制备盐酸西替利嗪凝胶剂,研究其体外透皮特性。方法:以卡波姆940为辅料制备西替利嗪凝胶剂,采用改良Franz扩散池,以离体大鼠皮肤为透皮屏障,采用HPLC法测定西替利嗪的透皮行为。结果:西替利嗪凝胶体外透皮释药方程为Q=110.03t+17.17(r=0.99),透皮速率为110.03μg/(cm2.h)。结论:西替利嗪凝胶具有良好的透皮效果,其体外经皮渗透符合一级动力学过程。Objective：To prepare cetirizine hydrochloride gel and study its skin penetration in vhro. Methods： Cetirizine gel was prepared with carbopol 940 as base material. Using Franz diffusion cell and excised rat skin in vitro as transdermal barrier. The cumulative permeation quantity of cetirizine was determined by HPLC. Results：The penetration equation of eetirizine gel was Q = 110. 03t ＋ 17. 17 （r = 0.99）. Conclusion：The penetration of cetirizine from the gel through the rat skin followed first-order kinetics.

关 键 词：盐酸西替利嗪 凝胶剂 体外透皮 

分 类 号：R94[医药卫生—药剂学]