简化LHRH刺激实验在儿童性早熟疾病鉴别诊断中的价值  

Value of simplified luteinizing hormone releasing hormone stimulation in differential diagnosis of precocious puberty

作　　者：刘德云[1] 韩正权 蒋惠珍[1] 张志红[1] 丁金霞[1] 周美玲[1] 

机构地区：[1]安徽医科大学第一附属医院儿科,230022 [2]安徽省桐城市中医院儿科

出　　处：《中国妇幼保健》2009年第30期4328-4329,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨简化LHRH(促性腺激素释放激素)刺激实验在儿童性早熟疾病鉴别诊断中的价值。方法:随机选择性早熟病例12例进行传统LHRH刺激试验(五点位法),并于静脉应用LHRH药物40 min时取静脉血,测定0、30、40、60、90、120 min 6个点位的LH、FSH值,分别比较确定0、40 min两个点位(简称两点位法)的LH峰值及LH/FSH比值;0、30、60、90 min 4个点位(简称四点位法)的LH峰值及LH/FSH比值;0、30、60、90、120 min 5个点位(简称五点位法)的LH峰值及LH/FSH比值。每例患者均分别以上述3种不同点位法得到的LH峰值及LH/FSH比值判断性早熟的类型,并分别将两点位法与五点位法、四点位法与五点位法LHRH刺激试验得到的试验结果进行比较,进行统计学处理。结果:以两点位法与五点位法判断的性早熟类型比较,差异无统计学意义(χ2=3.2,P>0.05);以四点位法与五点位法判断的性早熟类型比较,差异无统计学意义(χ2=0.22,P>0.05)。结论:简化LHRH刺激实验在儿童性早熟的鉴别诊断,尤其是年幼儿童性早熟的鉴别中具有重要价值。Objective：To explore the value of simplified luteinizing hormone releasing hormone（LHRH） stimulation in differential diagnosis of precocious puberty.Methods：12 children with precocious puberty underwent traditional LHRH stimulation（5 time-points）,then venous blood samples were taken at 0,30,40,60,90 and 120 minutes after LHRH to detect the levels of LH and FSH,peak value of LH and ratio of LH/FSH were compared at different time points including two time-points（0 and 40 minutes）,four time-points（0,30,60 and 90 minutes） and five time-points（0,30,60,90 and 120 minutes）.The types of precocious puberty were determined according to peak value of LH and ratio of LH/FSH,and the results were compared among different methods.Results：There was no significant difference in types of precocious puberty between two time-points and five time-points as well as between four time-points and five time-points（P〉0.05）.Conclusion：Simplified LHRH stimulation plays an important role in differential diagnosis of precocious puberty.

关 键 词：性早熟 刺激试验 鉴别诊断 

分 类 号：R725.8[医药卫生—儿科]