普伐他汀治疗慢性舒张性心力衰竭的临床研究  

The effects of Pravastatin in the treatment of heart failure

作　　者：洪梓岭[1] 

机构地区：[1]河南省商丘市第一人民医院,476000

出　　处：《中国医学创新》2009年第30期3-5,共3页Medical Innovation of China

摘　　要：目的研究他汀类药物治疗慢性舒张性心力衰竭的临床效果。方法选择2007年1月至2008年1月笔者所在医院收治的舒张性心力衰竭患者50例作为研究对象,在常规予以强心、利尿、硝酸酯类药物治疗的基础上加用普伐他汀治疗6个月,同时选择20例相似患者作为对照组,随访观察患者心功能改善情况、治疗效果情况。结果两组患者各心功能监测指标与治疗前比较,差异有统计学意义(P<0.05,P<0.01),其中,治疗后患者左心室质量(LVM)、舒张早期血流的峰值流速(EPFV)、舒张早期血流流速积分(ETVI)、A/E、收缩期峰值血流流速积分/总流速积分(ATVI/TTVI)和心功能NYAH分级评分改善程度他汀组与对照组比较,差异有显著性(P<0.05)。治疗后对照组总有效率为65.0%,他汀组总有效率为82.0%,两组间比较,差异有非常显著性(P<0.01)。结论他汀类药物——普伐他汀治疗舒张性心力衰竭效果较好,且可明显改善患者的心功能。Objective To study the treatment effects of statin drug on the patients with chronic diastolic heart failure, Methods Fifty cases of diastolic heart failure patients were studied in our hospital, who took Pravastatin for 6 months based on conventional heart, diuretic, nitrate drugs treatmeut. While twenty similar patients chose as a control group. The improvement of cardiac function and treatment effect in patients were observed. Results The two groups of patients with indicators for monitoring the cardiac function compared with those before treatment, the difference was statistically significant （P 〈 0.05, P 〈 0.01 ）. And LVM, EPFV, ETVI, A/E, ATVI/TTVI and NYAH heart functional classification score improved in patients with statin group after treatment compared with the control group, there was a significant difference between them （ P 〈 0.05 ）. The total effective rate was 65.0% in control group after treatment, while in statin group, the total effective rate was 82.0%, the difference was significant between the two groups （ P 〈 0.01 ）. Conclusion The statins - Pravastatin treatment of diastolic heart failure is better and can improve cardiac function in patients.

关 键 词：心力衰竭 舒张性 普伐他汀 他汀类药物 

分 类 号：R541.6[医药卫生—心血管疾病] R972.6[医药卫生—内科学]