血浆NT-proBNP与COPD肺动脉高压的相关性研究  

作　　者：钱文霞[1] 朱敏锋[1] 徐春明[1] 

机构地区：[1]苏州大学附属张家港医院呼吸内科,215600

出　　处：《当代医学》2009年第31期8-9,共2页Contemporary Medicine

摘　　要：目的研究血浆氨基末端脑钠肽前体(NT-PROBNP)水平与慢性阻塞性肺疾病患者肺动脉高压(PH)的相关性。方法用超声心动图测量73例慢性阻塞性肺疾病患者的肺动脉收缩压(PASP),根据PASP大小分为对照组(<30mmHg),轻度PH组(30～49mmHg),中重度PH组(≥50mmHg)。用双抗体夹心免疫荧光法(ELMA)检测血浆NT-proBNP水平。结果各组间NT-proBNP水平有显著性差异(P<0.05或P<0.01),血浆NT-proBNP水平与肺动脉压力呈正相关(r=0.7974,P<0.01)。采用多元线性回归分析排除年龄、肾功能的干扰后,二者仍然呈正相关(r=0.6785,P<0.01)。结论NT-proBNP水平随着PH加重而升高,两者呈正相关,NT-proBNP可作为判断PH严重程度的指标之一。Objective To research the correlation of N-Terminal pro-Brain Natriuretie peptide （NT-pro BNP） levels in serum with pulmonary artery Hypertension（pulmonary hypertension, PH）in patients with chronic obstructive pulmonary disease（COPD）. Methods 73 patients with COPD were measured pulmonary artery systolic pressure（PASP） by echocardiography. All patients were divided into three groups according to PASP：control group（〈30mmHg）, mild PH group（30-49mmHg） and mederate-severe PH group（〉50mmHg）. NT-pro BNP levels of plasma were measured by double-antibody sandwich immunoassay（ELMA）. Results The three groups were statistically different （P〈0.05 or P〈0.01） from each other on NT- pro BNP levels of plasma. NT-pro BNP level correlated with PH（r= 0.7974, P〈0.01）. After ruling out the influence of age, renal function by multiple linear regression, NT-pro BNP levels still correlated with PH（r=0.6785, P〈0.01）. Conclusion There is an increasing lendency of NT-pro BNP level companied increasing pulmonary pressure. NT-pro BNP may be a reliable index to show the change of pulmonary pressure and PH seveity.

关 键 词：氨基末端脑钠肽前体 慢性阻塞性肺疾病 肺动脉高压 

分 类 号：R563.9[医药卫生—呼吸系统] R543.2[医药卫生—内科学]