52例肥胖儿童血糖、胰岛素和抗胰岛素抗体检测结果分析  

Determination of serum glucose,insulin and antibody against insulin in obese children:results and analysis of 52 cases

作　　者：孙梅[1] 毕旭明[1] 王永平[1] 宋淑英[1] 李长贤[1] 

机构地区：[1]山东省德州市人民医院

出　　处：《中国实用儿科杂志》1998年第6期343-344,共2页Chinese Journal of Practical Pediatrics

摘　　要：目的：从免疫与糖代谢的关系方面探讨儿童肥胖症的发病机制。方法：对５２例肥胖儿童及４０例健康儿童进行血糖、胰岛素水平、抗胰岛素抗体水平及葡萄糖耐量试验的检测对比分析。结果：肥胖组牛乳喂养儿抗胰岛素抗体水平明显高于母乳喂养儿（ｔ＝２５３，Ｐ＜００５）；肥胖组血胰岛素水平（２０９７±８９６）ｍＵ／Ｌ和抗胰岛素抗体水平（２１９±１３１）％与对照组比较差异有非常显著意义（Ｐ＜００１）。结论：肥胖儿童存在胰岛素抵抗现象，早期牛乳喂养与抗胰岛素抗体的产生及肥胖症有一定的关系。Objective:To study the pathogenesis of obese children on the relationship between immunology and glucose metabolism.Methods:The 52 obese children and 40 healthy children as control were determined to have contrast and analysis on glucose,insulin,antibody against insulin in blood and the glucose tolerance test.Results:The level of antibody against insulin in cow's milk-fed obese group was higher than that in breast fed group(t=2 53,P<0 05).There were obvious difference in the concentration of insulin,antibody against insulin between obese group and control group(P<0 01).Conclusion:Insulin resistance exists in obese children.Early-stage cow's milk-feeding is related to the production of antibody against insulin and obesity in children.

关 键 词：肥胖症 抗胰岛素抗体 儿童 胰岛素 血糖 

分 类 号：R725.892[医药卫生—儿科] R723.14[医药卫生—临床医学]