清宫汤镇静作用的实验研究  

Experimental Study of Sedative Effect of Qinggong Decoction

作　　者：李越兰[1] 陆红[1] 张丽英[1] 

机构地区：[1]浙江中医药大学,浙江杭州310053

出　　处：《中国中医药信息杂志》2009年第11期27-28,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：浙江省教育厅资助(20060712)

摘　　要：目的研究清宫汤镇静、催眠的药理作用。方法50只小鼠随机分成5组,即生理盐水组、安定组及清宫汤低、中、高剂量组,安定组给予0.1 mL/10g灌胃给药,其他4组按照0.2 mL/10 g灌胃给药,记录给药前后自主活动,测定给予戊巴比妥钠阈上催眠剂量小鼠的睡眠时间及统计阈下剂量的睡眠动物数,另采用尼可刹米致惊厥小鼠模型,观察给予清宫汤后小鼠惊厥发生率的变化。结果清宫汤3.0、 6.0 g/kg剂量能明显抑制小鼠的自主活动,延长戊巴比妥钠阈上剂量的小鼠睡眠时间,增加戊巴比妥钠阈下催眠剂量所致睡眠动物数,并能显著对抗尼可刹米致小鼠惊厥的作用。结论清宫汤有明显的镇静、催眠、抗惊厥作用。Objective To study the pharmacological effects of Qinggong Decoction on sedation and hypnosis. Methods Fifty mice were randomly divided into five groups： NS group, diazepam group, and low-, mid-, high-dose Qinggong Decoction group. Diazepam group was given 0.1 mL/10 g diazepam, and other four groups were given 0.2 mL/10 g corresponding drugs. Spontaneous activities before and after ig. were recorded and the sleeping time of mice with pentobarbital sodium （superthreshold dosage） and the number of the sleeping mice with pentobarbital sodium （subthreshold dosage） were measured. Convulsion model induced by nikethamide was used to observe the change of the seizure rate in mice after given Qinggong Decoction. Results Qinggong Decoction （3.0, 6.0 g/kg） could obviously inhibit spontaneous activities of mice, prolong the sleeping time of mice with pentobarbital sodium （superthreshold dosage） and increase in the number of the sleeping mice with pentobarbital sodium （subthreshold dosage）, and had markedly anticonvulsant effect in mice induced by nikethamide. Conclusion Qinggong Decoction has obvious effects of sedation, hypnosis and anticonvulsion.

关 键 词：清宫汤 镇静 催眠 抗惊厥 小鼠 

分 类 号：R289.11[医药卫生—方剂学]