白花丹血清指纹图谱的初步研究  

Preliminary Study on Serum Fingerprint of Plumbago Zeylanica

作　　者：胡佳惠[1] 闫明 霍仕霞[1] 

机构地区：[1]石河子大学药学院,新疆石河子832003 [2]新疆维吾尔自治区维吾尔医药研究所,新疆乌鲁木齐830049

出　　处：《中国中医药信息杂志》2009年第11期36-37,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家科技支撑计划(2007BAI48B00;2007BAI48B06)

摘　　要：目的对民族药材白花丹进行血清指纹图谱的初步研究,为确定白花丹的药效成分奠定基础。方法建立白花丹醇提取物、口服白花丹后大鼠含药血清和空白血清的HFLC指纹图谱的分析方法,确定白花丹中的入血成分。结果在白花丹含药血清中发现了1个入血成分。结论1个入血成分可能成为白花丹的体内直接作用物质。Objective To sieve the bioactive constituents of Plumbago zeylanica, serum pharmacochemistry research was performed. Method Based on the establishment of HPLC fingerprints of Plumbago zeylanica, the constituents absorbed into blood were determined by comparing the HPLC fingerprints of the methanol extracts, medicated serum samples and blank serum sample. Results One compound absorbed into blood was detected, the other might be metabolites of the original constituent. Conclusion The one onstituent absorbed into blood was possible bioactive component of Plumbago zeylanica.

关 键 词：白花丹 高效液相色谱法 指纹图谱 血清药物化学 

分 类 号：R284.1[医药卫生—中药学]