出生前摄入酒精的大鼠尾壳核生后早期发育神经元AREAP定量图像分析研究  

Early Postnatal Development of Caudate Putamen of Rat Exposed to Alcohol PrenatallyQuantitative Image Pattern Analysis Study of AREAP of the Neurons

作　　者：黄文铎 柯国平 章祖陈 许海云 李春芳 

出　　处：《湖北医科大学学报》1998年第4期301-304,310,共5页

摘　　要：以１６只在出生前经母体摄入酒精的ＳＤ乳鼠及相同数量的正常ＳＤ乳鼠分别作为实验和对照材料，采用以神经元ＡＲＥＡＰ为参数的定量图像分析方法，研究了出生前摄入酒精的大鼠尾壳核的生后早期发育。结果提示酒精有延缓大鼠尾壳核神经元的排列由密变疏的发育过程。此影响在生后第１ｄ可以看到，直至第７ｄ仍未完全消失，而在此后。In this study 16 pups from the SD pregnant rats fed with 25%(V/V) alcohol(1.5 ml/100 g BW) over a 7 day period, from gestational day 8 through 14, and 16 pups from the SD pregnant rats untreated with alcohol were used as the experimental and control animals, respectively. The parameter for quantitative image pattern analysis was the area proportion(AREAP) of the neurons in the caudate putamen(CPu) of rat. The result suggested that postnatal developmental process in which the rangement of the neurons in CPu was from dense to spare, was delayed by prenatal exposing to alcohol prenatally. This effect was observable on the day 1 and had not completely disappeared on the day 7. Nevertheless, a compensatory process occured in the experimental animals after this stage.

关 键 词：酒精中毒 病理学 尾壳核 纹体 胚胎 大鼠 

分 类 号：R725.956[医药卫生—儿科] R322.81[医药卫生—临床医学]