pH敏感型壳聚糖结肠定位凝胶的制备和体外释放性能  

Study on preparation and in vitro release of the oral colon-specific drug delivery systems based on pH sensitive Chitosan

作　　者：熊艳[1] 吴学文[1] 

机构地区：[1]湘潭大学化学化工学院,湖南湘潭411105

出　　处：《中国医院药学杂志》2009年第21期1823-1826,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:以阿司匹林为模型药制备壳聚糖pH敏感结肠定位给药系统,并考察其体外释药行为。方法:以N-磷酸化壳聚糖衍生物(NPCP)作为药物载体,利用戊二醛交联制备了固载模型药物的凝胶,并研究该载药凝胶在模拟人体胃肠道环境中的释放情况。结果:在人工胃液中药物释放较少,在pH6.8和pH7.8的磷酸盐缓冲液中缓慢释放,且pH越高,释药速度越快,无交联pH7.8在7h内释药完全,交联的载药凝胶86h释放完毕。结论:NPCP有望作为药物载体用于开发具有pH敏感性的口服定位给药系统。OBJECTIVE To study the preparation and properties of chitosan pH sensitive colon-specific drug delivery systems based on chitosan derivatives. METHODS N-phosphated chitosan polyelectrolyte （NPCP） was used as a drug carrier,glutaraldehyde was used as a cross-linker, solid gel contained the model drug, aspirin, were prepared, and the properties in vitro release of the preparation in the human gastrointestinal tract simuIation environment. RESULTS The drug was released least in the artificial gastric juice, while the preparation was slowly released in pH 6.8 and 7.8 phosphate buffers, the higher the pH, the faster the rate of release. The preparation without cross-linked was completely released in 7 hours at pH7.8, at the same time the preparation with cross-linked was completely released after 86 hours at Ph 7. 8. CONCLUSION NPCP is expected to be used as a pH sensitive drug carrier in colon-specific drug delivery systems.

关 键 词：壳聚糖 结肠定位 PH敏感 阿司匹林 

分 类 号：R943[医药卫生—药剂学]