氯吡格雷抵抗与血瘀证关系分析  

The Relationship Analysis of Clopidogrel Resistance and Blood Stasis Syndrome

作　　者：严威[1] 吴小盈[2] 孙红[2] 李灿东[1] 陈慧[2] 

机构地区：[1]福建中医学院 [2]福建省立医院福建医科大学省立临床学院,福州350001

出　　处：《江西中医学院学报》2009年第5期63-65,共3页Journal of Jiangxi College of Traditional Chinese Medicine

基　　金：卫生部科学研究基金福建省卫生教育联合攻关计划项目(WKJ2008-2-59)

摘　　要：目的:探讨不同程度血瘀证与生化氯吡格雷抵抗(CR)及临床CR的关系。方法:收集2008年1月～2009年6月连续住院的中国汉族心脑动脉血栓性疾病患者365例,其中男235例,女130例,平均年龄67.12±9.12岁,比较不同程度血瘀证与生化CR(即ADP诱导的最大血小板聚集率(MPA)在氯吡格雷治疗10天后比服药前下降≤10%)和临床CR(PCI术后心血管事件再发)之间的关系。结果:(1)在365例心脑动脉血栓性疾病的患者中,重度血瘀证组患者在服氯吡格雷后,MPA下降的幅度为10.58%±9.19%,明显小于轻度血瘀证组(17.50%±8.85%,P<0.01);(2)在365例心脑动脉血栓性疾病的患者中,重度血瘀证组中出现生化CR的患者人数为132例,占64.4%,明显高于轻度血瘀证组31例(占19.4%,P<0.01);(3)在130例行PCI患者中,重度血瘀证组心脑血管事件再发人数为29例,占46.8%,明显高于轻度血瘀证组12例(占17.6%,P<0.01)。结论:不同程度的血瘀证不仅与生化CR密切相关,而且增加了中国汉族PCI术后患者心血管事件再发的危险。Object：To explore the relationship among valying degree of blood stasis syndrome ,biochemical clopidogrel resistance （CR） and clinical CR . Method：Collect 365 Han Chinese patients with cardiovascular and cerebrovascular disease who was hospitalized in January 2008 - June 2009. Of whic, h 235 cases of male, 130 cases of women,The average age is 67. 12 ±9. 12years. Compare varying degree of blood stasis syndrome to biochemical CR （ Maximum platelet aggregation rate That ADP-induced decreases less than 10% after clopidogrel treatment in ten days ）and clinical CR（ cardiovascular events recurrent after PCI）. Resuhs：l. In 365 cases of ischemic cardiovascular and cerebrovaseular disease patients,after patients with severe blood stasis syndrome served clopidogrel, the decreasing rate of MPA significantly is greater than that in mild blood stasis syndrome group;2 In 365 cases of ischemie cardiovascular and cerebrovascular disease patients,there are 132 patients with severe blood stasis syndrome who have biochemical CR. The rate is 64. 4% , which is higher than that of mild blood stasis syndrome group. 3. In 365 cases of patients undergoing percutaneous coronary intervention （PCI） ,there are 29 patients undergoing cardiovascular and cerebrovascular events （46. 8% ） ,which is higher than mild blood stasis syndrome group. Conclusion：Varying degree blood stasis syndrome has relationship with biochemical CR ,and increases risk of cardiovascular events recurrence after PCI in Chinese Han patients.

关 键 词：中医证型 血瘀证 氯吡咯雷抵抗(CR) 

分 类 号：R255.7[医药卫生—中医内科学]