2008年湖北省手足口病流行病学分析  

Study on Epidemic Characteristics of Hand-foot-mouth Disease in Hubei Province in 2008

作　　者：杨坤[1] 汪霞[1] 彭丹[1] 刘京涛[1] 李慧娟[1] 官旭华[2] 邹典定[1] 赵东赤[1] 

机构地区：[1]武汉大学中南医院儿科,湖北武汉430071 [2]湖北省疾病控制中心传染病防治所,湖北武汉430072

出　　处：《医学新知》2009年第5期271-274,277,共5页New Medicine

摘　　要：目的分析2008年湖北省手足口病（HFMD）疫情的特点，为合理防治提供临床流行病学依据。方法对2008年湖北省17个地市州上报HFMD病例的流行病学资料进行回顾性分析；分析不同肠道病毒亚型的流行特点。结果2008年湖北省共上报HFMD病例21145例，其中重症病例12例，死亡1例。发病时间主要在5～7月份，发病年龄以0～5岁儿童为主。病原学检测提示，湖北省各地肠道病毒呈散发状态，以肠道病毒71型（EV71）感染为主（50．8％），科萨奇病毒（Cox）A16占18．0％，其他肠道病毒占31．2％，但局部地区流行的肠道病毒不同。粪便中肠道病毒检出率（84．0％）最高，其次为咽拭子（62．0％）；而EV71在咽拭子中检出率最高（49．3％），其次为疱疹液（39．2％）。病毒在体内存留时间在10d以上。结论2008年湖北省流行的HFMD呈散发状态，局部地区以EV71流行为主。Objective To analyze the epidemic characteristics of hand-foot-mouth disease （HFMD） in Hubei Province in 2008, and provide clinical epidemiological evidence for the prevention and control of HFMD. Methods All the cases of HFMD from 17 districts in Hubei Province were analyzed retrospectively. Partial patients＇specimens were collected to detect pathogens by RT-PCR method. Results A total of 21145 cases of HFMD were reported, including 12 severe cases and 1 death. Most were infected in May to July with the age of 05 years old. 593 cases were given etiology detection, 203 cases showing enterovirus 71 （EV71） positive （50.8%）. In different sources of samples, stool was the most positive sample with enterovirus （ 84.0% ）, followed by throat swab 62.0% and herpes 47. 1%. EV71 was checked out from different time courses; onset of 5days showed the highest rate of positive （76.1%）, its excretion through stool can persist for more than 10 days. Conclusion The outbreak of HFMD in Hubei Province in 2008 distributed with enterovirus, and it was mainly caused by EV71 in some local areas.

关 键 词：手足口病 肠道病毒感染 EV71 流行病学 

分 类 号：R512.5[医药卫生—内科学]