筋骨草总黄酮治疗系膜增生性肾小球肾炎大鼠的实验研究  

Experimental Study of Ajuga Flavonoids in the Treatment of Mesangial Proliferative Glomerulonephritis of Rats

作　　者：南丽红[1,2] 彭卫华[3] 方泰惠[1] 徐曾涛[2] 

机构地区：[1]南京中医药大学药学院,南京210029 [2]福建中医学院,福州350108 [3]南京军区福州总医院,福州350025

出　　处：《中国中医急症》2009年第11期1849-1850,1855,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：福建省卫生厅青年科研课题(No.2006-1-35);陈可冀中西医结合发展基金.福建省中西医结合老年性疾病重点实验室开放课题资助项目(No.CKJ2008088)

摘　　要：目的观察筋骨草总黄酮对系膜增生性肾小球肾炎(MsPGN)大鼠的治疗作用。方法采用大鼠改良慢性血清病MsPGN模型,于造模第5周末检测尿蛋白。将尿蛋白阳性者随机分为模型组、雷公藤多苷组、筋骨草总黄酮组,另设正常对照组。于造模第6周起开始给药,6周后测定各组大鼠的24h尿蛋白定量、血生化,光镜下观察肾组织病理形态学变化。结果与模型组相比,筋骨草总黄酮组尿蛋白显著降低,TP明显升高、BUN、Scr、TG、Tch降低,且Tch和ALT明显低于雷公藤多苷组。形态学观察显示,筋骨草总黄酮组较模型组损害减轻。结论筋骨草总黄酮对MsPGN大鼠有较好的治疗作用,且无明显肝损害。Objective： To explore the therapeutic effects of total flavonoids of Ajuga （TFA） on mesangial prolif- erative glomerulonephritis （MsPGN） in rats. Methods： MsPGN rat model was induced by the improved chronic serum sickness. After five weeks, the positive urinary protein rats were randomly divided into the model group, the tripteryglum wilfordii polyglycosidium （TWP） group and the TFA group. Normal rats were considered as the control group. MsPGN rats were treated with corresponding drugs from the sixth week. At succeeding six weeks later, all rats were detected 24h urinary protein and blood biochemistry. Pathomorphological changes in renal tissue were observed under microscopy. Results： Compared with the model group, TFA could reduce the urinary protein, BUN, Ser, TG and Tch, significantly. Meanwhile, it could increase TP. The morphological observation showed that TFA could mitigate the damage more than that in model group. Compared with TWP, TFA can significantly reduce Tch and ALT. Conclusion： Total flavonoids of Ajuga have the therapeutic effects on MsPGN rats and the protective fanction on liver.

关 键 词：筋骨草 黄酮 系膜增生性肾小球肾炎 大鼠 

分 类 号：R285.5[医药卫生—中药学]