3种麻醉剂对兔Oddi括约肌肌电运动的影响  

Effect of 3 Kinds of Anaesthetics on the Myoelectric Motility of Sphincter of Oddi in Rabbits

作　　者：刘永康[1] 李智华[1] 王冰洋[1] 何谦[1] 王小军[1] 董家鸿[1,2] 

机构地区：[1]第三军医大学西南医院全军肝胆外科研究所,重庆市400038 [2]解放军总医院全军肝胆外科研究所,北京市100853

出　　处：《中国药房》2009年第31期2418-2420,共3页China Pharmacy

摘　　要：目的:研究麻醉剂速眠新、氯胺酮、戊巴比妥钠对兔Oddi括约肌(SO)肌电运动的影响。方法:取家兔24只,采用改良的Thomas法间置空肠建立SO肌电运动检测通道,术后10d时将存活的16只随机分为3组,分别静脉注射速眠新(n=6)、氯胺酮(n=5)、戊巴比妥钠(n=5),在清醒状态及麻醉起效后5min各组耳缘静脉注射胆囊收缩素(CCK)20、100ng.kg-1(2次给药至少间隔3min),期间连续记录3种麻醉剂给药前、后及CCK给予后的SO肌电运动,以运动指数及其增幅、兴奋效应持续时间等指标表示,同时以未加麻醉剂时给予CCK前、后的肌电运动为对照。结果:与给予麻醉剂前比较,速眠新和氯胺酮组给药后SO肌电运动指数明显增加(P<0.05),而戊巴比妥钠组变化不明显;与对照组比较,CCK使速眠新和氯胺酮组SO肌电运动指数增幅降低,戊巴比妥钠组运动指数增幅增加、兴奋效应持续时间延长(P<0.05)。结论:3种麻醉剂对兔SO肌电运动均有影响,以速眠新和氯胺酮的影响较大,戊巴比妥钠影响相对较小。OBJECTIVE： To explore the influence of sumianxin, ketamine and sodium pentobarbital on the myoelectric motility of Sphincter of Oddi （SO） . METHODS： 24 adult rabbits were used in this study, and the access to the myoelectric motility recording was achieved by interposition of jejunum stump with modified Thomas method. The survived rabbits were divided into 3 groups after 10 days＇ recovery time, each group was anesthetized with sumianxin（ n = 6）, ketamine（ n - 5）, and sodium pentobarbital（n = 5）, respectively. Cholecystokinin （CCK, 20,100 ng · kg^- 1） was injected in conscious state and after the rabbits were completely anesthetized 5 min was recorded （the interval between CCK injections was at least 3 min） .The change of myoelctric motility were recorded before and after CCK application without anaesthetics, and the enhancement of motility index and change of effective duration were evaluated. The effects of 3 anaesthetics on the myoelectric motility were compared with the conscious state before anesthesia with or without CCK application. RESULTS： In comparison with the conscious state, myoelectric motility of SO was significantly enhanced in sumianxin and ketamine group（P〈0.05）, but no significant change was observed in sodium pentobarbital group. Exogenous CCK stimulates the spikes of SO in all rabbits, this effect was significantly weakened by sumianxin and ketamine, whereas sodium pentobarbital totally magnified the excitation role of CCK including increased motility index and prolonged effective duration（P 〈 0.05）. CONCLUSION：All the three drugs alter the myoelectric motility of SO in rabbits, especially for sumianxin and ketamine, while sodium pentobarbital has relatively less influence.

关 键 词：麻醉剂 兔 ODDI括约肌 肌电运动 

分 类 号：R965[医药卫生—药理学] R971.2[医药卫生—药学]