盐酸戊乙奎醚减少老年女性患者术后躁动的作用  

作　　者：王彪[1] 陈坚伟[1] 王刚生[1] 徐康清[1] 

机构地区：[1]中山大学附属第一医院麻醉科,510080

出　　处：《中国临床实用医学》2009年第11期57-59,共3页China Clinical Practical Medicine

摘　　要：目的 本研究将盐酸戊乙奎醚作为老年女性患者麻醉前用药，与传统的氢溴酸东莨菪碱进行比较，评价其对术后躁动的影响。方法选择年龄65以上的老年女性患者。气管内插管全身麻醉下择期行甲状腺手术治疗的老年患者，随机分两组。麻醉前30min，Ⅰ组患者予盐酸戊乙奎醚1mg肌肉注射。Ⅱ组患者氢溴酸东莨菪碱0．3mg肌肉注射。记录用药前、用药后10min、20min、30min的收缩压、舒张压、心率、脉搏氧饱和度、麻醉时间，手术时间和苏醒时间和术后躁动发生情况。结果Ⅰ组患者术后躁动的发生率比Ⅰ组低，差异有统计学意义（P〈0．05）。结论 与氢溴酸东莨菪碱相比，盐酸戊乙奎醚显著减少老年女性患者术后躁动的发生率，是一种较理想的麻醉前用药。Objective To compare the effects of penehyclidine hydrochloride and scopolamine hydrobromide on postoperative restlessness, both of which were administrated as premedication in old women operation. Method Eighty old women patients, underwent thyroid operation under general anesthesia, were randomized to two groups with 40 cases each. 30 minutes before anesthesia, group I received intramuscularly penehyelidine hydrochloride 1 mg, group 11 received intramuscularly scopolamine hydrobromide 0. 3 mg. Heart rate, blood pressure ,oxygen saturation were recorded just before premedication, at 10,20,30 minutes after drug administration. The incidence rate of postoperative restlessness, the duration of anesthesia, the duration of surgery and the duration of palinesthesia were recorded as well. Results The incidence rate of postoperative restlessness in group I was lower than that in group Ⅱ （ P 〈 0.05 ）. Conclusions penehyclidine hydrochloride could reduce the incidence rate of postoperative restlessness in old women, and penehyelidine hydroehloride was desirable premedication compared with scopolamine hydrobromide.

关 键 词：盐酸戊乙奎醚 氢溴酸东莨菪碱 麻醉前用药 术后躁动 

分 类 号：R614[医药卫生—麻醉学]