三维打印技术制备植入式药物控释装置及体外释药研究  

Implantable and controlled drug delivery device fabricated by three dimensional printing and its releasing character in vitro

作　　者：黄卫东[1] 郑启新[2] 刘先利[1] 李胜方[1] 

机构地区：[1]黄石理工学院化学与材料工程学院,湖北黄石435003 [2]华中科技大学同济医学院附属协和医院骨科,武汉430022

出　　处：《中国新药杂志》2009年第20期1989-1994,共6页Chinese Journal of New Drugs

基　　金：湖北省教育厅科研项目(Q20093002)

摘　　要：目的:研究三维打印技术制备植入装置和体外释放行为。方法:以庆大霉素为模型药物,利用三维打印技术制备以聚乳酸为载体的植入药物控释装置,比较植入式给药制剂的传统工艺方法和三维打印方法,同时进行结构分析、体外释药行为实验。结果:三维打印成形技术可以制备复杂内部结构的装置,其释药特征与所设想的复杂释药行为一致。结论:三维打印成形技术应用于制药工程有着其他技术无法竞争的独特优势。Objective：The present study investigated the implantable and controlled drug delivery device （CDDD） by 3D printing, and the releasing character of the devices. Methods： The CDDD was fabricated by 3D printing technique with L-PLA as pharmaceutical excipient, and gentamicin （GTM） was used as a model drug. As compared with the 3D process, the conventional process was also used for fabrication the IDDS. The cross-sectional morphology and the in vitro release were simultaneously tested to evaluate the devices. Results：A type of implant- able CDDD with complicated architectures was designed and built with 3D printing process,and its in vitro release behavior was tested to meet initial design criteria. Conclusion： The 3D printing technique using in pharmaceutical field have the peerless advantage over the conventional technique.

关 键 词：三维打印 植入式药物控释装置 庆大霉素 体外释放 

分 类 号：R943.4[医药卫生—药剂学]