蜂王浆不同组分对荷S180肿瘤小鼠免疫效果的影响  

Inhibitory Effect of Active Components of Royal Jelly on S180 Sarcoma Growth of Mice

作　　者：曾星凯[1,2] 颜伟玉[1] 谢国秀[3] 吴小波[1] 曾志将[1] 

机构地区：[1]江西农业大学蜜蜂研究所,南昌330045 [2]江西省吉安市农业局,江西吉安331300 [3]江西省劳动卫生职业病防治研究所,南昌330006

出　　处：《湖北农业科学》2009年第10期2523-2525,共3页Hubei Agricultural Sciences

基　　金：国家现代蜜蜂产业技术体系资助项目(nycytx-43-kxj15);江西省教育厅资助项目(赣教技字[2007]161号)

摘　　要：将新鲜蜂王浆经过180目滤网过滤,滤液再逐步经过0.50μm、0.10μm和0.05μm的无机陶瓷膜过滤,分别得到了5种蜂王浆活性组分,测定新鲜蜂王浆及各活性组分的癸烯酸含量。将88只荷瘤小鼠随机分为环磷酰胺组(40 mg/kg)、模型对照组、蜂王浆及各组分实验组,连续灌胃4周。观察小鼠一般状况,测定抑瘤率和脏体系数,以探讨蜂王浆各组分对荷S180肿瘤小鼠的免疫效果。结果表明,除新鲜王浆先后经过180目滤网,0.50μm和0.10μm无机陶瓷膜过滤的组分外,其他各蜂王浆组分与对照组比较对降低瘤体重量差异不显著,其中E组抑瘤率最高达45.52%。说明蜂王浆不同活性组分对荷S180肿瘤小鼠抗癌作用有差异。[Objective] To investigate the effect of active components of royal jelly on S180 sarcoma growth of mice.[Methods] The fresh royal jelly through a filter with 180 meshes was filtered by inorganic membranes with size of 0.50μm、 0.10μm and 0.05μm,5 groups of different components of royal jelly were got,then the content of 10-HDA were determined.88 tumor-bearing mice were randomized into cyclophosphamide（CTX） group,negative control and royal jelly groups,fed for 4 weeks continuously.The general condition of mice was observed,the inhibitory rate of tumor growth and organic index were determined and analyzed.[Results] The tumor growth was significantly inhibited and tumor weight was reduced in experimental groups except group D,highest to 45.52% in comparison with the tumor control group.[Conclusion] Inhibitory effect of different active components of royal jelly on S180 sarcoma growth of mice was different.

关 键 词：蜂王浆活性成分 小鼠 抑制作用 S180肉瘤 

分 类 号：S896.3[农业科学—特种经济动物饲养]