体外受精-胚胎移植术后4～6小时卧床休息的必要性探讨  

Necessary or unnecessary:a prolonged bed rest following embryo transfer

作　　者：王佩玉[1] 赵军招[1] 周红卫[1] 林金菊[1] 林文琴[1] 周洁春[1] 周颖[1] 叶碧绿[1] 

机构地区：[1]温州医学院附属第一医院生殖医学中心,浙江温州325000

出　　处：《中国实用妇科与产科杂志》2009年第11期847-849,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的探讨体外受精-胚胎移植(IVF-ET)术后4～6h卧床休息的必要性。方法对2007年6-12月在温州医学院附属第一医院生殖医学中心因各种不孕原因接受IVF治疗的675例不孕症患者,行常规体外受精(IVF)或单精子卵胞浆内注射(ICSI)共690个新鲜周期。分为两组:A组290例共296个周期胚胎移植后患者立即起床自行步行至病房,休息0.5～1h离院;B组385例共394个周期胚胎移植后患者用推车送至病房并卧床休息4～6h离院。比较两组患者的HCG阳性率、临床妊娠率、异位妊娠率、早期流产率。结果两组的HCG阳性率分别为52.36%和46.45%,差异有统计学意义(P<0.05)。两组的种植率分别为28.11%和28.66%,临床妊娠率分别是43.92%和39.08%,生化妊娠率分别是4.39%和4.57%,异位妊娠率分别是4.05%和2.79%,流产率分别是2.03%和4.57%,两两比较差异均无统计学意义(P>0.05)。两组月经周期第2～5天血卵泡刺激素、注射HCG日血雌二醇、平均获卵数、平均受精数、平均优胚数及移植日胚胎数以及胚胎移植数目比较,差异也均无统计学意义(P>0.05)。结论胚胎移植术后患者立即自行步行且短时间休息并不影响妊娠结局,胚胎移植后4～6h卧床休息是不必要的。Objective To assess whether immediate bed rest following in vitro fertilization （IVF） and embryo transfer （ET） is necessary. Methods Data were collected from the Reproductive Medical Center of the First Affiliated Hospital of Wenzhou Medical College. 675 women with all kinds of infertility factors underwent 690 IVF treatment cycles. They were randomized into study group （Group A, n =296） and control group （Group B, n =394）. Women in the Group A walked immediately following embryo transfer and left hospital ＇after rest for half an hour to 1 hour and women in the Group B were pushed away out of operating room with a cart and then have a bed rest for 4-6 hours in our center. Compare and analyze the two groups＇rates of HCG positive, clinical pregnancy, biochemical pregnancy, ectopic pregnancy, early abortion and so on. Results The HCG positive rate were 52. 36% （group A） and 46.45% （group B）, respectively, with statistically significant difference between the two groups （P 〈0. 05 ）. The implantation rate for both groups were 28. 1% and 28.66% respectively, clinical pregnancy rate were 43.92% and 39.08 % , and biochemical pregnancy rate were 4. 39% and 4. 57% , ectopic pregnancy rate 4. 05% and 2. 79% , early abortion rate 2. 03% and 2. 57%. All of which has no statistically significant difference between the two groups （ P 〉 0. 05 ）. There were also no statistical significant difference in the level of basal FSH, the level of E2 on the HCG injection day, and the average number of oocytes retrieval, fertilization, high-quality embryos, transferred embryos among patients （ P 〉 0. 05 ）. Conclusion These results suggest that immediate ambulation and a shorter bed rest after embryo transfer had no effect on the pregnancy results, so a prolonged bed rest .following embryo transfer was not necessary.

关 键 词：体外受精 胚胎移植 卧床休息 妊娠率 

分 类 号：R71[医药卫生—妇产科学]