血清唾液酸 上皮膜抗原及甘氨酰脯氨酸二肽氨基肽酶单项及联合检测诊断胃癌的临床研究  

The clinical value of measurements of serum SA,EMA and GPDA in the diagnosis of gastric cancer

作　　者：项文坤[1] 熊锋宝[1] 杨铁一[1] 付唆林[1] 

机构地区：[1]南昌大学医学院第三附属医院消化一科

出　　处：《中国实用内科杂志》2009年第11期1012-1014,共3页Chinese Journal of Practical Internal Medicine

基　　金：江西省卫生厅资助基金(20080262);江西省南昌市科技局资助基金(20081137)

摘　　要：目的探讨血清唾液酸(SA)、上皮膜抗原(EMA)和甘氨酰脯氨酸二肽氨基肽酶(GPDA)单项及联合检测对胃癌的诊断价值。方法对2008年3～12月南昌大学医学院第三附属医院收治的30例经电子胃镜及病理检查确诊的胃癌患者及25例胃癌前病变患者及35例非萎缩性胃炎患者的SA、EMA、GPDA分别进行测定,分析两两差异性,同时分析胃癌患者血清SA、EMA、GPDA与胃癌临床生物学行为的关系。结果胃癌组血清SA、GPDA浓度明显高于非萎缩性胃炎、胃癌前病变组(P<0.05)。胃癌组血清EMA浓度与非萎缩性胃炎、胃癌前病变组浓度无统计学意义(P>0.05)。除非萎缩性胃炎组GPDA与年龄有统计学意义(P<0.05),SA浓度在肿瘤分化程度组间差异有统计学意义(P<0.05)外,其余各组与临床生物学行为均无统计学意义(P>0.05)。结论检测血清SA和GPDA对于胃癌的诊断有重要参考价值。检测血清EMA对胃癌诊断可能没有价值。胃癌患者血清SA、GPDA与胃癌临床生物学行为相关,检测血清SA、GPDA将有助于判断胃癌的转移、复发及监测预后。Objective To study the clinical value of serum SA, EMA and GPDA in the diagnosis of gastric cancer. Methods To detect serum SA,EMA and GPDA in 30 patients with gastric cancer patients,25 patients with gastric precancerous lesions and 35 patients with non-atrophicgastritis with electronic gastroscope and pathological examination confirmed, compared the differences betwwen the groups, and analyze the relationship between the expressions of them and clinical biology of gastric carcinoma. Results The serum concentrations of SA and GPDA in gastric carcinoma are remarkably higher than those in non-atrophic gastritis and gastric precancerous lesions （P 〈 0. 05 ）. Serum EMA is not a valuable marker in the diagnostic of gastric cancer（ P 〉 0. 05 ）. The concentrations of GPDA in non-atrophic gastritis group are agerelated（P 〈 0. 05 ） and the concentrations of SA in the invasion stage is obviously higher than the localized stage（ P 〈 0.05 ） ,There are no obvious correlations between the levels of the other groups with the clinical biology behavior of gastric carcinoma （ P 〉 0. 05 ）. Conclusion It has an important reference value for the diagnosis of gastric cancer to detect serum SA and GPDA. SA and GPDA together can improve the accuracy of the diagnosis of gastric cancer. EMA serum possibly has no diagnostic value for gastric cancer. The expressions of SA, GPDA in serum are related to the biology behaviors of gastric carcinoma, and the concentrations of SA, GPDA in serum is helpful in judging metastasis and recrudescence, and monitoring prognosis.

关 键 词：胃癌 胃癌前病变 非萎缩性胃炎 SA EMA GPDA 

分 类 号：R5[医药卫生—内科学]