光氧化反应的研究 Ⅵ.敏化光氧化反应合成胆甾烯烃衍生物  

STUDIES ON PHOTOOXIDATION Ⅵ. SYNTHESIS OF CHOLESTENE DERIVATIVES BY SENSITIZED PHOTOOXIDATION

作　　者：江致勤[1] 曾代迅 

机构地区：[1]兰州大学应用有机化学实验室 [2]同济大学测试中心光化学研究室,上海200092

出　　处：《感光科学与光化学》1989年第1期53-59,共7页Photographic Science and Photochemistry

基　　金：开放基金

摘　　要：本文应用敏化剂荧光黄素(LF)和9,10-二氰蒽(DCA)研究了三种胆甾烯烃(1—3)在几种溶剂中的敏化光氧化。该反应提供了一种合成5或7-位取代胆甾烯烃衍生物方便和实用的方法。实验发现,LF敏化胆固醇1于苯中的光氧化导致3β-羟基-5烯-7-酮(1c,40％)的生成。敏化剂与溶剂对于此光化学合成反应的影响也进行了讨论。In this work, the sensitized photooxidation of three cholestenes (1-3) in several solventswas studied by using sensitizers of lumiflavin (LF) and 9, 10-dicyanoanthracene (DCA). This reaction provided a convenient and practical method of synthesizing 5- or 7-substituted choles-tene derivatives. It was found that LF-sensitized photooxidation of cholesterol 1 in benzene ledto the formation of 3β-hydroxy-cholest-5-en-7-one (Ic, 40%). The influence of sensitizers andsolvents upon the photochemical synthetic reaction was also discussed.

关 键 词：甾族烯烃 光氧化 光化学合成 

分 类 号：O625.155[理学—有机化学]