FOXM1转录活性的调控及其与肿瘤的关系  

Regulation of the FOXM1 transcription activity and its relationship with tumor

作　　者：董玉芳(综述)[1] 张莉萍(审校)[1] 

机构地区：[1]重庆医科大学附属第一医院检验科,400016

出　　处：《国际肿瘤学杂志》2009年第10期736-738,共3页Journal of International Oncology

摘　　要：FOXM1属于FOX基因家族，仅特异性表达于增殖期细胞中。FOXM1可被多因子、多细胞信号通路共同参与的复杂过程激活，且其转录活性在细胞周期进展过程中逐渐增加。FOXM1在许多恶性肿瘤和肿瘤细胞株中均有表达，是肿瘤增殖所必需的转录因子，是临床上肿瘤治疗的新靶点。FOXM1 is a member of the FOX gene family, and is specifically expressed in proliferating cells. Its transcription activity is activated by complicated process involving in multi-factor and multi-cell signaling pathways and is elevated during cell cycle progression. FOXM1 is found to be expressed in varieties of malignant tumors and tumor cell lines. Being an essential transcription factor for tumor proliferation, FOXM1 is considerd to be a potential new target for tumor therapy.

关 键 词：细胞周期 肿瘤 FOXM1 

分 类 号：R979.1[医药卫生—药品] R730.4[医药卫生—药学]