Effects of trimetazidine on atrial structural remodeling and platelet activation in dogs with atrial fibrillation  

作　　者：HAN Wei LI Wei-min ZHOU Hong-yan HUO Hong WEI Na DONG Guo CAO Yong ZHOU Guo YANG Shu-sen 

机构地区：[1]Department of Cardiology, First Clinical College of Harbin Medical University, Harbin, Heilongjiang 150001, China

出　　处：《Chinese Medical Journal》2009年第18期2180-2183,共4页中华医学杂志（英文版）

摘　　要：Atrial fibrillation （AF） is one of the most common .arrhythmias in clinical practice. AF results in electrophysiological alterations which involve increased atrial effective refractory period and atrial effective refractory period dispersion, reduced rate adaptation of atrial effective refractory period, and slowed atrial conduction. These variances promote their own maintenance-AF begets AF.1 Previous study suggested that Ca^2＋ overload and metabolic derangement contributed to electrophysiological remodeling in AF. However, we did not demonstrate a persistent disturbance in energy metabolism during AF in our previous study,Atrial fibrillation （AF） is one of the most common .arrhythmias in clinical practice. AF results in electrophysiological alterations which involve increased atrial effective refractory period and atrial effective refractory period dispersion, reduced rate adaptation of atrial effective refractory period, and slowed atrial conduction. These variances promote their own maintenance-AF begets AF.1 Previous study suggested that Ca^2＋ overload and metabolic derangement contributed to electrophysiological remodeling in AF. However, we did not demonstrate a persistent disturbance in energy metabolism during AF in our previous study,

关 键 词：ATRIALFIBRILLATION structural remodeling THROMBOSIS TRIMETAZIDINE 

分 类 号：R686[医药卫生—骨科学]