稀土磁性纳米微球Dy:Fe_3O_4@PHEMA-Tb的载药性研究  

Study on drug loading properties of rare earth magnetic nano-microspheres Dy:Fe_3O_4@PHEMA-Tb

作　　者：孟繁宗[1,2] 谢宏伟[1] 翟玉春[1] 

机构地区：[1]东北大学材料与冶金学院,沈阳110004 [2]德州学院先进材料研究所,山东德州253023

出　　处：《材料与冶金学报》2009年第3期234-240,共7页Journal of Materials and Metallurgy

基　　金：山东省自然科学基金资助项目(Q2006F01)

摘　　要：以稀土磁性纳米微球Dy:Fe3O4@PHEMA-Tb为载体材料,丝裂霉素C(MMC)为模型药物,在一定条件下制备了具有生物相容性、低毒性等特点的稀土磁性药物微球(MMC-PHEMA-FMPM s).通过正交实验设计考察了制备MMC-PHEMA-FMPMs工艺条件对磁性微球的载药量和包封率的影响,用高效液相色谱(HPLC)测定稀土磁性药物微球的载药量和包封率,固体永磁铁测试稀土磁性药物微球的体外磁响应性.结果表明,稀土磁性纳米微球具有较高的载药量和包封率,体外药物释放受pH影响较大,磁响应性显著,是靶向给药的良好载体.Rare earth magnetic drug - microspheres MMC - PHEMA - FMPMs with biocompatibility and low poisoness were prepared under a certain condition by taking rare earth magnetic nano -microspheres Dy： Fe3O4 @ PHEMA-Tb as carrier and mitomycin C as pharmaceutical model. The design of orthogonal experiment detected the effect of process conditions of preparation on drug loading and embedding ratio, which of MMC - PHEMA - FMPMs was measured by HPLC and magnetic responsibility by solid permanent magnet. The results show that the rare earth magnetic nano - microspheres has a high drug loading and embedding ratio, a great effect of relaxation ability in vitro on pH, a very remarkable magnetic responsibility and therefore can be used as high - quality drug carrier.

关 键 词：稀土磁性纳米微球 丝裂霉素C 载药量 包封率 磁响应性 

分 类 号：O632[理学—高分子化学]