rhBMP-2/nHA/Co复合膜异位成骨的实验研究  

An experiment on ectopia osteogenesis of rhBMP-2/nHA/Co compound membrane

作　　者：张莉[1] 马宁[1] 车彦海[1] 边晓为[1] 

机构地区：[1]长春吉林大学口腔医学院,130041

出　　处：《实用口腔医学杂志》2009年第5期650-653,共4页Journal of Practical Stomatology

基　　金：吉林大学研究生创新基金资助项目(编号:20091030)

摘　　要：目的:观察rhBMP-2/nHA/Co复合膜异位诱导成骨的能力。方法:构建nHA/Co复合膜和rhBMP-2/nHA/Co复合生物膜,分别植入裸鼠后肢大腿肌囊,于10、20、30 d后观察成骨情况,并作比较。结果:rhBMP/nHA/Co组材料在裸鼠肌囊内出现骨样结构,异位成骨的能力较nHA/Co组强。结论:动物实验中Co、nHA均为BMP的良好缓释载体,此复合膜能有效的诱导异位成骨。Objective：To evaluate the ectopia osteogenesis ability of rhBMP-2/nHA/Co compound membrane.Methods：Two membranes were fabricated：（1） nHA/Co group（2） rhBMP-2/nHA/Co group.Both of them was evaluated after implantation under thigh muscle of nude mice for 10,20,30 days.Results：More bone-like structures in rhBMP-2/nHA/Co group were found,than that in nHA/Co group.Conclusion：Collagen and nano-HA are suitable sustained release systems for rhBMP-2 in animal experiment and the rhBMP-2/nHA/Co compound membrane can effectively induce ectopia osteogenesis.

关 键 词：Ⅰ型胶原 重组人骨形成蛋白-2 异位成骨 

分 类 号：R318.08[医药卫生—生物医学工程]