内置式光纤引导的大鼠经口气管插管方法  

Method of orotracheal intubation directed by optical fiber laying in the tracheal catheter in rats

作　　者：朱永城[1] 江慧琳[1] 陈晓辉[1] 林珮仪[1] 王华军[1] 李缨[1] 

机构地区：[1]广州医学院第二附属医院急诊科,510260

出　　处：《中华生物医学工程杂志》2009年第4期307-311,共5页Chinese Journal of Biomedical Engineering

基　　金：广州市医药卫生科技项目（2006-YB-165）

摘　　要：目的利用气管导管内置入直径0．9mm的光纤作为光源，建立一种新的大鼠经口气管插管方法。方法SD大鼠40只分2组：（1）气管导管内置入光纤引导下的经口气管插管组（光纤组，n=20），（2）传统光源直视下的经口气管插管组（传统组，n=20）。比较2组经口气管插管时间、插管次数、一次插管成功率、拔除气管插管后1周的存活率。结果光纤组的插管时间（36．00±16．43）S、插管次数（1．05±0．22）次、一次插管成功率95％均优于传统组[（86．20±56．48）S，（1．75±1．02）次，60％，P〈0．05]，但2组大鼠拔管1周后的存活率差异无统计学意义。结论气管导管内置光纤引导下的经口气管插管法是一种创新的大鼠气管插管方法，能实现快速、有效、准确的气管插管。Objective To develop a new method of orotracheal intubation in adult rats by using a 0.9 mm-in optical fiber-laying in the tracheal catheter as a source of light. Methods Sprague-Dawley rats were randomly divivded into two groups for orotracheal intubation： （1） the optical fiber group （n=20）： an optical fiber was utilized as a light to visualize the trachea and vocal cords; （2）the conventional group （n= 20）： a comprehensive rodent model of orotracheal intubation was developed. The intubation time and intubation frequency, the success rate of the first intubation were compared between the optical fiber group and the conventional group. After intubation the rats were mechanically ventilated for 60 min, with the tidal volume at 0.65 ml/100 g and respiratory frequency at 60/min. And then the endotracheal tube was removed, the smvival rate was compared between two groups in 1 week. Results The time and frequency of intubation were significantly less in the optical fiber group than those in the conventional group [ （36.00±16.43） s vs （86.20±56.48） s, 1.05±0.22 vs 1.75±1.02, P〈0.05） 1. The success rate of the first intubation in the optical fiber group was obviously higher than that of the optical fiber group （95% vs 60%, P〈0.05）. There was no obviously difference in the survival rate after extubation in 1 week between groups （100% vs 80%, P〉0.05）. Conclusion The improved orotracheal intubation technique with optical fiber is a method of innovation, which can obtain a quick, effective and accurate intubation.

关 键 词：插管法 气管内 大鼠 光纤 成功率 存活率 

分 类 号：R614[医药卫生—麻醉学]