银屑病外周血CD4^+CD25^+Foxp3^+调节性T细胞的表达  

Expression of CD4^+ CD25^+ Foxp3^+ regulatory T cells in peripheral blood of patients with psoriasis

作　　者：韩凌[1] 黄琼[1] 方栩[1] 项蕾红[1] 郑志忠[1] 

机构地区：[1]复旦大学附属华山医院,上海200041

出　　处：《中国麻风皮肤病杂志》2009年第10期722-724,共3页China Journal of Leprosy and Skin Diseases

基　　金：国家自然科学基金(30600542)

摘　　要：目的:检测CD4^+CD25^+Foxp3^+调节性T细胞在不同类型银屑病患者中的表达。方法:应用流式细胞仪检测外周血中CD4^+CD25^+Foxp3^+调节性T细胞的表达。结果:红皮病型银屑病患者外周血中CD4^+CD25^+Foxp3^+调节性T细胞明显高于其他类型银屑病和正常对照组(P<0.05);斑块状银屑病CD4^+CD25^+Foxp3^+T细胞比例高于点滴状患者(P<0.05);脓疱型银屑病患者中脓疱存在患者调节性T细胞比例明显低于脓疱消退患者(P<0.05)。结论:CD4^+CD25^+Foxp3^+调节性T细胞通过抑制效应T细胞在银屑病的病情活动中可能发挥重要作用。Objective： To detect the expression of CD4^＋CD25^＋Foxp^3＋regulatory T cells in different types of psoriasis. Methods： The expression of CD4^＋CD25^＋Foxp^3＋regulatory T cells in the peripheral blood was detected and analyzed by flow cytometric analysis in 45 patients with psoriasis. Results： The proportion of CD4^＋CD25^＋Foxp^3＋ regulatory T cell was significantly higher in patients with psoriatic erythroderma than in healthy controls and other types of psoriasis （ P 〈 0.05）. The expression of CD4^＋CD25^＋Foxp^3＋ regulatory T cell was higher in plaque type of psoriasis than in guttate type （ P 〈 0.05）, and it was higher in active pustule psoriasis than in pustule - vanishing patients （ P 〈 0.05）. Conclusion： CD4^＋CD25^＋Foxp^3＋ regulatory T cells may play an important role in activity of psoriasis by serfregulation of T cell.

关 键 词：银屑病 CD4 CD25 FOXP3 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]