特应性皮炎外周血白介素17水平检测  

Detection of serum IL- 17 in the patients with atopic dermatitis

作　　者：李建红[1] 李萍[1] 刘建中[1] 崔荣[1] 冯进云[1] 

机构地区：[1]深圳市儿童医院皮肤科,深圳518026

出　　处：《中国麻风皮肤病杂志》2009年第10期742-743,共2页China Journal of Leprosy and Skin Diseases

摘　　要：目的:检测特应性皮炎(AD)患者血中白介素17(IL-17)水平。方法:采用双抗体夹心ELISA法检测66例特应性皮炎患者和50名正常对照者血中IL-17含量。结果:患者组血中IL-17水平明显高于对照组(P<0.001)。重度组高于中度组(P<0.001),中度组与轻度组无统计学差异。结论:IL-17可能在AD患者的免疫发病机制中发挥作用。Objective： To detect the serum interleukin 17 （IL- 17） level in the patients with atopic dermatitis. Methods： The level of IL- 17 in the sera of 66 patients with atopic dermatitis and 50 normal controls was measured by enzyme linked immunosorbent assay （ELISA）. Results： The serum IL- 17 level was higher in patients than in controls （P〈0.001）. The patients with severe grade of the disease had higher serum IL- 17 level than the patients with moderate and mild severe grade of the disease （P 〈 0.05）. There was no significant difference in the serum IL - 17 level between moderate group and mild group of the disease. Conclusion： IL- 17 may play a role in the immunopathogenesis of atopic dermatitis.

关 键 词：特应性皮炎 白介素17 

分 类 号：R758.2[医药卫生—皮肤病学与性病学] R392[医药卫生—临床医学]