血清同型半胱氨酸对冠心病及合并高血压病患者冠状动脉造影临床分析  

The relationship between the levels of serum homocysteine and results of coronary angiography in coronary heart disease patients and with essential hypertension

作　　者：王晓俐[1] 王晓玲[2] 朱兴雷[1] 

机构地区：[1]山东大学附属省立医院心血管科,山东济南250021 [2]山东大学附属省立医院检验科,山东济南250021

出　　处：《医学影像学杂志》2009年第9期1144-1146,共3页Journal of Medical Imaging

基　　金：山东省保健医学科研基金资助项目:2007BZO4

摘　　要：目的:探讨血清同型半胱氨酸(Hcy)对冠心病(CHD)合并高血压病(EH)冠状动脉造影结果的分析。方法:根据冠状动脉造影结果,将冠状动脉造影正常者24例为对照组,冠状动脉主要分支有明显斑块、狭窄者72例为观察组。再根据有无高血压病史将患者分为单纯冠状动脉病变组(a组)39例,冠状动脉病变伴高血压病组(b组)33例,正常对照组(c组)24例,分析血清同型半胱氨酸对冠心病及合并高血压的患者冠状动脉狭窄程度、病变支数的影响。结果:血清Hcy水平与冠状动脉狭窄程度、病变支数明显相关,狭窄程度越显著,病变支数越多,其血清Hcy水平越高(P<0.01)。血清Hcy水平在冠状动脉病变合并高血压病组比单纯冠状动脉病变组及对照组,明显增高(P<0.01)。结论:血清Hcy水平与冠心病、高血压密切相关,检测血清Hcy对于冠心病及高血压预防、诊断和病情监控都具有重要临床价值。Objective：To study the relationship between the levels of serum homocysteine（Hcy） and results of coronary angiography in coronary patients with or without essential hypertension（EH）.Methods：Seventy-two patients and 24 control were examined the levels of serum homocysteine and hospitalized to receive percutaneous transluminal coronary angioplasty and stent.Thirty-nine patients only with coronary heart diseases（group a）,33 coronary patients with essential hypertension（group b） and 24 control（group c） were studied,according to the results of coronary angiography. Then, to analyze the relationship between the levels of serum homocysteine and results of coronary angiography in these three groups. Results：There is a statistical significanee between the levels of serum homocysteine and the crucial amount of branches of coronary. The higher the levels of serum homocysteine, the more crucial amount of branches of coronary （ P 〈 0. 01）. Moreover, the levels of serum homoeysteine were highest in group b compared with group a and group e. Conclusion： There is a good relationship between the levels of serum homeeysteine and results of coronary angingraphy. To prevents and diagnosis of coronary heart disease and hypertension, it has a high clinical value to measure the levels of serum homeeysteine.

关 键 词：同型半胱氨酸 冠状动脉造影 高血压 冠心病 

分 类 号：R541[医药卫生—心血管疾病] R815[医药卫生—内科学]