巨细胞病毒感染患者治疗前后外周血染色体着丝粒点畸变率比较  

Changes of peripheral blood chromosomal centromere aberration in patients with cytomegalovirus infection after anti-viral treatment

作　　者：高岚[1] 刘彦慧[2] 黎丽芬[2] 吴亚敏[2] 王明波[2] 石静[2] 袁冰[2] 宋娟[2] 何永明[2] 魏代奎[2] 

机构地区：[1]河南省人民医院检验科,河南郑州450003 [2]中山大学附属东华医院医学遗传学实验室,广东东莞523110

出　　处：《南方医科大学学报》2009年第9期1846-1847,1850,共3页Journal of Southern Medical University

基　　金：广东省东莞市科技局医学科研项目(20060315)

摘　　要：目的研究巨细胞病毒感染孕妇治疗前后外周血染色体着丝粒点(Cd)变异率的变化,为优生优育积累实验依据。方法选择巨细胞病毒感染且出现早期流产的孕妇62例,采用抗病毒和免疫调节对其进行综合治疗,在治疗前后取其静脉血以同步银染法检测染色体Cd变异率,探讨巨细胞病毒对Cd的致畸作用和抗病毒治疗对Cd的影响。结果治疗前后母体外周血Cd畸变率具有显著性差异(P<0.0001),抗病毒治疗可使Cd畸变率降低。结论巨细胞病毒是导致外周血Cd畸变的因素,Cd畸变率检测可反应病毒感染程度和治疗后恢复程度。Objective To study the changes of peripheral blood chromosomal centromere aberration in patents with cytomegalovirus （CMV） infection after anti-viral treatment. Methods Sixty-two patients with early spontaneous abortion and CMV infection analyzed for their peripheral blood chromosomal centromere using simultaneous silver staining before and after anti-viral treatment. Results The patients with CMV infection had high rate ofcentromere aberration, which was decreased significantly after anti-viral treatment （P〈0.0001）. Conclusion CMV infection is a risk factor for peripheral blood chromosomal centrimere aberration. Anti-viral treatment can decrease the rate ofcentrimere aberration aberration. Detection of peripheral blood chromosomal centrimere aberration allows the assessment of the severity of infection and the condition after treatment.

关 键 词：早期流产 染色体着丝粒点 巨细胞病毒 

分 类 号：R714.2[医药卫生—妇产科学]