ω-3鱼油脂肪乳对胃肠道肿瘤病人术后免疫功能和炎性反应的影响  

The effect of ω-3 fish oil on immunologic function and inflammatory reaction of patients with gastrointestinal tumor after operation

作　　者：刘鑫[1] 辛福泽[1] 张彦波[1] 米曰堂[1] 郭震[1] 邵峰[1] 徐春英[1] 杨道贵[1] 

机构地区：[1]聊城市人民医院胃肠外科,山东聊城252000

出　　处：《肠外与肠内营养》2009年第5期280-282,285,共4页Parenteral & Enteral Nutrition

摘　　要：目的:观察ω-3鱼油脂肪乳对胃肠道肿瘤病人术后细胞免疫功能和炎性反应的影响。方法:42胃肠道肿瘤病人随机分为对照组(20例)和研究组(22例)。对照组病人给予低热量PN治疗,而研究组加用ω-3鱼油脂肪乳。术后第1天起,连续5 d接受等氮、等热量的PN支持。观察病人术前、术后第1天和第6天外周血中T淋巴细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+比值)和血清C反应蛋白(CRP)的变化,并进行统计分析。结果:两组病人术后第1天CD3+、CD4+和CD4+/CD8+比值均有所下降,术后第6天研究组CD3+、CD4+和CD4+/CD8+比值上升,而对照组上升不明显。两组病人术后第1天CRP水平明显上升,术后第6天又明显下降,但仍高于术前水平,且研究组较对照组低。结论:胃肠道肿瘤病人术后早期应用ω-3鱼油脂肪乳能改善病人细胞免疫功能,抑制机体炎性反应,促进病人术后康复。Objective ： To investigate the effect of ω-3 fish oil on immunologic function and inflammatory reaction of patients with gastrointestinal tumor after operation. Methods： 42 cases with gastrointestinal tumor were divided into control group and study group. The patients in control group were treated with hy- pocalorie parenteral nutrition, and those in study group received ω-3 fatty acids additionally. The total par- enteral nutrition was transfused from the first day to the fifth day after operation. CD3 ＋ , CD4 ＋ , CD8 ＋ , CD4 ＋/CD8 ＋ and CRP of the two groups were detected on the day before the operation, the first and sixth day after operation. Results ： CD3 ＋ , CD4 ＋ , CD8 ＋ ter operation, and increased study group. The CRP level after five days of parenteral of the two groups increased CD4 ＋/CD8 ＋ of the two groups were dropped af- nutrition..However, the increase was obviously in obviously affbr operation but it also dropped obvi-ously after five days TPN support especially in the study group. Conclusion ： Early total parenteral nu- trition contained ω-3 fatty acids can improve immunologic function and control inflammatory reaction. It may have beneficial effect on the recovery of patients with gastrointestinal tumor after operation.

关 键 词：Ω-3鱼油脂肪乳 胃肠道肿瘤 免疫功能 炎性反应 

分 类 号：R459.3[医药卫生—治疗学] R735[医药卫生—临床医学]