阻塞性睡眠呼吸暂停低通气综合征患者肾上腺素β1受体基因多态性与其心血管系统并发症的关系  

The association between polymorphism of β1-adrenoceptor genes and cardiovascular complication in obstructive sleep apnea-hypopnea syndrome patients in HaM population

作　　者：陈晓阳[1] 王蓓[1] 刘卓拉[1] 王强[1] 

机构地区：[1]山西医科大学第二医院呼吸科,太原030001

出　　处：《中华结核和呼吸杂志》2009年第10期736-738,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：基金项目：山西省卫生厅科技攻关资助项目（200517,200741）

摘　　要：目的探讨OSAHS患者肾上腺素β1受体基因多态性与其心血管系统并发症的相关性。方法采用聚合酶链反应-限制性片段长度多态性（PCR—RFLP）技术对2007年2月至12月山西医科大学第二医院经多导睡眠监测（PSG）诊断的192例OSAHS患者肾上腺素β1受体Gly389Arg位点的基因多态性进行检测，分析该位点基因型（CC组、CG组及GG组）与OSAHS患者PSG监测参数及心血管事件的相关性。采用方差分析、X2检验及t检验进行统计学分析。结果不同基因型频率两两比较CC组明显高于CG和GG组，等位基因频率C明显高于G。CC组的睡眠时最低血氧饱和度（minSaO2）明显低于GG和CG组，睡眠期间SaO2低于90％的时间占总睡眠时间的百分比（T90）及最长呼吸暂停时间（Tmax）均较高。3组间窦性心动过缓的发生率差异无统计学意义（P〉0．05），CC组高血压、冠状动脉粥样硬化性心脏病、心律失常及肺源性心脏病的发生率均明显高于CG组和GG组（P〈0．05）。结论OSAHS患者肾上腺素β1受体Gly389Arg位点的CC基因型可能与其心血管并发症的发生有关，C等位基因可能是易感基因。Objective To investigate the association between polymorphism of β1-adrenoceptor genes and cardiovascular complication in obstructive sleep apnea-hypopnea syndrome （OSAHS） patients. Method The Gly389Arg polymorphism of β1-adrenoceptor genes was identified by poiymerase chain reaction-restricted fragment length polymorphism assay in 192 OSAHS patients of ＂ HAM＂ population of China. The effect of polymorphisms in the OSAHS group on parameters of polysomnography and cardiovascular complication was analyzed. Analysis of variance, t test and chi-square test were used for statistics. Result The distributions with CC genotype were significantly higher than those with CG/GG genotype. The frequencies with C allele were significantly higher than those with G allele. The OSAHS patients with CC genotype had higher percentage of time of oxygen saturation lower than 90% （T90） and longer apnea time （Tmax） than those with CG/GG genotype. The lowest saturation of blood oxygen （ minSaO2 ） in patients with CC genotype was significantly lower than that in patients with CG/GG genotype. Cardiovascular diseascs（P 〈 0.05） except sinus bradycardia were more common in patients with the CC genotype（P 〈0. 05）. Conclusion The Gly389Arg CC genotype of β1-adrenoceptor genes may be involved in cardiovascular complication in OSAHS, and the C allele may be an important candidate gene.

关 键 词：睡眠呼吸暂停 阻塞性 肾上腺素能Β1 多态性 心血管疾病 

分 类 号：R686[医药卫生—骨科学]