离子交换树脂吸附更昔洛韦的动力学与热力学研究  

Kinetics and Thermodynamics of Absorption of Ganciclovir by Ion Exchange Resin

作　　者：周伟[1] 唐宇[1,2] 谢欢[1] 刘姹[1] 杨大坚[1] 陈新滋[1] 

机构地区：[1]深圳市中药药学及分子药理学研究重点实验室,广东深圳518057 [2]湖南中医药大学药学院,长沙410208

出　　处：《中国药学杂志》2009年第17期1327-1331,共5页Chinese Pharmaceutical Journal

基　　金：深圳市科技计划项目(2D200609180044B)

摘　　要：目的研究更昔洛韦药物树脂交换动力学与热力学。方法用动边界模型描述了更昔洛韦交换过程的动力学;用热力学参数描述了更昔洛韦交换过程的热力学。结果确定更昔洛韦交换行为的速度控制步骤为颗粒扩散,更昔洛韦交换过程的表观活化能为-27.95kJ·mol-1,交换反应的自由能变化△G>0,焓变△H0m<0,熵变△S<0。结论通过对更昔洛韦与树脂的动力学与热力学研究,为更昔洛韦药物树脂释药系统提供理论依据。OBJECTIVE To study the exchange kinetics and thermodynamics behavior of ganciclovir-resin complexes. METHODS Moving Boundary Model was applied to describe the kinetics of exchange process. Thermodynamic parameters were used to describe the thermodynamic behavior of exchange process. RESULTS The dominant procedure was ion diffusion through particles. The exchange activation energies were -27.95 KJ.mol-1. The AG value was greater than zero. The reaction enthalpy △H0m was less than zero. The reaction entropy △S was also less than zero. CONCLUSION The exchange kinetics and thermodynamics behavior of ganciclovir-resin complexes could supply the theory for the ion exchange resin-ganciclovir drug delivery system.

关 键 词：更昔洛韦 离子交换树脂 动力学 热力学 

分 类 号：R969.1[医药卫生—药理学]