心脏移植患者环孢素A药动学研究  

Pharmacokinetics of Cyclosporine A in Heart Transplant Recipients

作　　者：金锐[1] 王珍[1] 韩毓博[1] 张一飞[1] 曲福军[1] 

机构地区：[1]哈尔滨医科大学附属第二医院临床药学药物研究所,黑龙江高校重点实验室,哈尔滨150086

出　　处：《中国药学杂志》2009年第17期1331-1333,共3页Chinese Pharmaceutical Journal

摘　　要：目的荧光偏振免疫法测定心脏移植患者连续服用环孢素A至稳态后的血药浓度并考查其药动学特点。方法采用荧光偏振免疫法测定5名心脏移植术后患者服药达稳态后单剂量po环孢素A每次100mg,bid后药物在体内的经时过程。结果5名心脏移植术后患者环孢素A的tmax为（1.60±0.55）h ρmax为（951.60±229.20）μg·L-1,t1/2为（6.53±2.40）h,AUC0~t为（5162.10±1355.01）μg·h·L-1。结论建立中国心脏移植患者环孢素A的稳态药动学参数。OBJECTIVE To determine the steady state concentration and the pharmacokinetics of cyclosporine A in the heart transplant recipients. METHODS A single dose of 100 mg CsA capsules twice daily was given to 5 heart transplant recipients of steady state. The concentrations of cyclosporine A in plasma were determined by SP-FPIA. RESULTS The main pharmacokinetic parameters of cyclosporine A were as follows： tma（1.60±0.55）h ρmax为（951.60±229.20）μg·L-1,t1/2（6.53±2.40）h,AUC0~t为（5162.10±1355.01）μg·h·L-1,respectively. CONCLUSION The study obtained the steady state pharmacokinetic parameters of CsA in Chinese heart transplant recipients.

关 键 词：环孢素A 荧光偏振免疫分析法 药动学 

分 类 号：R969.1[医药卫生—药理学]