子宫内膜异位症和女性性激素之关系  

Relationship between enodometriosis and female hormones

作　　者：谢培珍[1] 张俐雅[1] 张黎铭[1] 

机构地区：[1]上海市第一人民医院

出　　处：《上海医学》1998年第11期636-638,共3页Shanghai Medical Journal

基　　金：上海市人事局留学回国人员科技活动经费资助

摘　　要：目的：通过对手术确诊为子宫内膜异位症的晚期患者进行女性性激素的测定，了解两者间的关系。方法：从妇科住院手术患者中，选择重度子宫内膜异位症患者作为对象，于滤泡期抽血测定促卵泡激素、促黄体生成素、垂体生乳激素、雌激素、孕激素、雄激素。根据术中所见病灶的部位、数目、大小和深度，按１９８５年美国生殖学会分期法给予评分，删除Ⅰ～Ⅲ期患者，晚期患者３５例。对照组４６例均来自门诊月经规则的健康妇女，于月经后一周抽静脉血作以上激素测定。结果：患病组体内的雌激素水平明显高于对照组（Ｐ＜０．０１），孕激素、雄激素、生乳素也高于对照组（Ｐ＜０．０５），促卵泡激素和促黄体生成素无明显变化（Ｐ＞０．０５）。患病组呈明显的内膜异位的病理改变，３５例中有２２例伴有子宫肌瘤（６２．９％）、５例伴有子宫内膜增生过长（１４．３％）。结论：重度（Ⅳ期）子宫内膜异位症患者体内雌激素水平明显增高，和孕激素、雄激素及垂体泌乳素有一定的关系。Objective:To find out the relationship between late stage endometriosis and the female hormones.Method:Blood was drawn from stage 4 hospitalized endometriosis patients during follicular stage to determine FSH, LH, PRL E2 and P. The patients were then divided into different stages according to the staging location, number and size of foci of and scored according to the method of American fertility association in 1985. Only 35 were concordant with stage 4 endometriosis, the control group consisted of 46 O.P.O.healthy subjects and blord was drawn to determine the above hormones as well one week after menstruation. Results: E2 was obviously higher in the patient group than that in the controls (P<0 01), while P, T and PRL were also higher in the patient group (P<0 05),FSH and LH showed no change (P>0.05) Among the patient group, 22/35 cases were also suffered from aberine myona (62.9%) and 5 had excessive endometrial hyperplasia (14.3%). Conclusion:Female hormonal assays of patients with endometriosis of stage 4 show positir relations, with elevations of E2, PRL, P and T. Elevation of E2,is also related to PRL, P and T to a certain degree.

关 键 词：子宫内膜异位 性激素 相关关系 

分 类 号：R711.710.2[医药卫生—妇产科学]